Clinical Trials Logo
  1. Home
  2. Heart Failure NYHA Class III
  3. NCT03592836

Diuretic Response in Advanced Heart Failure: Bolus Intermittent vs Continuous INfusion — DRAIN  

Heart Failure NYHA Class III Clinical Trial

Official title:
Diuretic Treatment in High Risk Decompensated Advanced Heart Failure. Bolus Intermittent Versus Continuous Infusion of Furosemide: a Randomized Controlled Trial.

Clinical Trial Summary

Loop diuretics are the main therapy for decongestion of patients with advanced acute heart failure. However, these patients often develop diuretic-resistance or even diuretic-refractoriness. In order to overcome such resistance to diuretic, the clinician can increase the dose of furosemide, or change the way of administration (continuous infusion versus boluses) or associate a different class of diuretics (thiazide diuretics, K+-sparing diuretics) up to the addition of low doses of inotropic agents to improve renal perfusion. At the present time there is no evidence in literature in advanced acute heart failure patients about the superiority of the treatment with furosemide in continuous infusion or in intermittent boluses. The aim of the study was to evaluate the efficacy of furosemide in boluses versus continuous infusion in advanced acute heart failure.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03592836
Study type Interventional
Source University of Turin, Italy
Contact
Status Completed
Phase Phase 3
Start date May 1, 2013
Completion date December 22, 2017
View Details
See also
  Status Clinical Trial Phase
Recruiting NCT04452149 - Algorithm Using LINQ Sensors for Evaluation And Treatment of Heart Failure N/A
Not yet recruiting NCT06097481 - Narrative Intervention for Chronic Illness- Heart Failure Trial (NICI-HF) Phase 1/Phase 2
Withdrawn NCT03005184 - Mechanism(s) Underlying Cardiovascular Effects of ARB/NEP Inhibition - Aim 2 Phase 2
Not yet recruiting NCT01669395 - Severe Heart Failure and Homebased Rehabilitation - An Intersectoral Randomized Controlled Trial N/A
Completed NCT05835063 - A Study to Improve Physician-Youth Communication and Medical Decision Making N/A
Completed NCT03895073 - HEart fAiluRe evaluaTion Questionnaire
Completed NCT03095196 - Multipolar CRT-d and Diabetes N/A
Recruiting NCT03180320 - Baduanjin-eight-silken-movement With Self-efficacy Building for Patients With Chronic Heart Failure (BESMILE-HF Study) N/A
Completed NCT06233695 - Gender-based Differences in the Outcome of Treatment With Aldosterone Antagonists in Patients With Heart Failure
Withdrawn NCT03947853 - Clinical Study to Evaluate the Predictive Value of the Heart Failure Questionnaire (HF-Q) for the Occurrence of Μajor Αdverse Cardiovascular Events (MACE) in Patients With Symptomatic Heart Failure
Recruiting NCT05934487 - PROACTIVE-HF-2 Trial Heart Failure NYHA Class II and III N/A
Recruiting NCT04829617 - Promoting Well-being and Health in Heart Failure N/A
Recruiting NCT03538990 - Effect of DASH Eating Pattern on Heart Failure Outcomes N/A
Recruiting NCT05487365 - Implementation and Cost-evaluation of a Smartphone-based Telemonitoring and Digital Support in Patients With HF N/A
Completed NCT01560871 - Effects of a Walking Program and Inspiratory Muscle Training in Individuals With Chronic Heart Failure N/A
Completed NCT03387813 - Hemodynamic-GUIDEd Management of Heart Failure N/A
Not yet recruiting NCT06270875 - Addressing Pain Through Navigator-Led Palliative Care Optimized for Heart Failure (ADAPT-HF) N/A
Enrolling by invitation NCT05885607 - Early Metabolic Adaptations to SGLT2 Inhibition in Heart Failure
Active, not recruiting NCT04012944 - SIRONA 2 Trial Heart Failure NYHA Class III N/A
Recruiting NCT05879887 - An Optimization Pilot to Optimize An Early Palliative Care Intervention for Advanced Heart Failure N/A