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NCT00156234 Clinical Trial

Skeletal Muscle Dysfunction in Heart Failure

Heart Failure, Congestive Clinical Trial

Official title:
Training and Congestive Heart Failure

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT00156234
Other study ID # TRUST-001
Secondary ID Helse ØstHelse o
Status Recruiting
Phase N/A
First received September 8, 2005
Last updated September 8, 2005
Start date March 2005

Study information
Verified date September 2005
Source Ullevaal University Hospital
Contact n/a
Is FDA regulated No
Health authority Norway:National Committee for Medical and Health Research Ethics
Study type Interventional

Clinical Trial Summary

Patients suffering from congestive heart failure report reduced exercise capacity. This skeletal muscle dysfunction is also detectable when using small muscle groups which should not put any demand on the heart.

We hypothesize that congestive heart failure has systemic effects that causes the skeletal muscle dysfunction.

Recruitment information / eligibility
Status Recruiting
Enrollment 45
Est. completion date
Est. primary completion date
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Both
Age group 40 Years to 78 Years
Eligibility Inclusion Criteria:

- Coronary Heart Failure

- Ejection fraction <35%

- NYHA 2-3

- Spirometry FEV1 > 80%

Exclusion Criteria:

- Cardiomyopathy

- Transplantation candidate

- Active malignancy

- Restraining skeletal-muscular disease

- Claudication in legs

- Hospitalized last 30 days due to acute ischemic episode

- Intravenous inotrope or vasodilatating drugs last 14 days prior to inclusion

- AMI last 8 weeks prior to inclusion

- Organized training last 4 months

- Smoking on daily basis last 4 months

- Creatinin < 150microliters/liter

Study Design

Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Single Blind, Primary Purpose: Educational/Counseling/Training

Related Conditions & MeSH terms

Intervention

Behavioral:
• One-knee extension ergometer

Locations
Country Name City State
Norway Institute for Experimental Medical Research Oslo
Norway Norwegian School of Sport Sciences Oslo

Sponsors (5)
Lead Sponsor Collaborator
Ullevaal University Hospital Norwegian Health Association, Norwegian School of Sport Sciences, The Research Council of Norway, University of Oslo

Country where clinical trial is conducted

Norway, 

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