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The Effect of Intranasal Insulin Administration on Cognitive Function After Cardiac Surgery.

Heart Diseases Clinical Trial

Official title:
The Effect of Intranasal Insulin Administration on Cognitive Function After Cardiac Surgery

Clinical Trial Summary

Decline in cognitive function after surgery occurs most commonly in older patients and patients undergoing major surgeries, such as heart surgery. Postoperative Cognitive Dysfunction (POCD) may last a prolonged period of time while Postoperative Delirium (POD) is a more acute disturbance in attention, awareness and cognition. The cause of POCD and POD are not fully understood, however some of the pathophysiology of POCD is similar to that of Alzheimer's disease (AD). Insulin given intravenously during heart surgery has been shown to preserve short and long-term memory function after the operation. Clinical trials further demonstrated that insulin given via the nose (intranasal) improves memory performance of patients with AD or cognitive impairment suggests that intranasal insulin also could be a therapeutic option for POCD and POD. This study is designed to examine the effect intranasal insulin on POCD and POD. The goal is to investigate whether administration of intranasal insulin during and after heart surgery improves cognitive function postoperatively.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03324867
Study type Interventional
Source McGill University Health Centre/Research Institute of the McGill University Health Centre
Contact Thomas Schricker, M.D., PhD.
Phone 5149341934
Email thomas.schricker@mcgill.ca
Status Not yet recruiting
Phase N/A
Start date April 2022
Completion date April 2023
View Details
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