Identifying Genes That May Increase the Risk for Heart Disease in African Americans

Heart Diseases Clinical Trial

Official title:

Health Disparities and CVD: Admixture Mapping in the Jackson Heart Study

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00344136
• Other study ID #: 1344
• Secondary ID: R01HL084107-01
• Status: Completed
• Phase: N/A
• First received: June 23, 2006
• Last updated: July 28, 2016
• Start date: September 2000
• Est. completion date: March 2004

Study information

• Verified date: October 2006
• Source: National Heart, Lung, and Blood Institute (NHLBI)
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Federal Government
• Study type: Observational

Clinical Trial Summary

Heart disease and stroke disproportionately affect African Americans in the United States. These conditions are likely caused by both environmental and genetic factors. This study will attempt to identify specific genes of African and European ancestral origins that may influence the development of heart disease in African Americans.

Description:

African Americans have a high risk of developing heart disease and stroke, and are more likely to die from heart-related illnesses than other racial and ethnic groups. A large majority of African Americans are descendants of both African and European ancestors who mixed five to six generations ago. Because only a few generations have passed since that time, it is still possible to identify specific genes, the basic units of heredity, as being either African or European in origin. This is a sub study of the Jackson Heart Study, which is examining the environmental and genetic factors that influence the development of heart disease in African Americans. In this study, researchers will examine genes from participants in the Jackson Heart Study to identify specific African and European genes that influence the development of heart disease in African American men and women.

This study will use genetic samples from individuals participating in the Jackson Heart Study. There will be no study visits for participants. Study researchers will examine the genetic samples and identify specific African and European genes that may influence the development of heart disease, high blood pressure, lipid disorders, left ventricular hypertrophy, and low birth weight.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 5302
• Est. completion date: March 2004
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 21 Years to 95 Years

Eligibility

Inclusion Criteria:

• Unrelated African Americans living in Hinds, Rankin, or Madison County, Mississippi enrolled in the Jackson Heart Study

Study Design

Time Perspective: Prospective

Related Conditions & MeSH terms

• Heart Diseases

Locations

Country	Name	City	State
United States	University of Mississippi School of Medicine	Jackson	Mississippi

Sponsors (1)

Lead Sponsor	Collaborator
National Heart, Lung, and Blood Institute (NHLBI)

Country where clinical trial is conducted

United States, 

References & Publications (2)

Patterson N, Hattangadi N, Lane B, Lohmueller KE, Hafler DA, Oksenberg JR, Hauser SL, Smith MW, O'Brien SJ, Altshuler D, Daly MJ, Reich D. Methods for high-density admixture mapping of disease genes. Am J Hum Genet. 2004 May;74(5):979-1000. Epub 2004 Apr 14. — View Citation

Wilson JG, Rotimi CN, Ekunwe L, Royal CD, Crump ME, Wyatt SB, Steffes MW, Adeyemo A, Zhou J, Taylor HA Jr, Jaquish C. Study design for genetic analysis in the Jackson Heart Study. Ethn Dis. 2005 Autumn;15(4 Suppl 6):S6-30-37. — View Citation