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Hearing Loss clinical trials

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NCT ID: NCT05664100 Terminated - Clinical trials for Hearing Loss, Sensorineural

First in Human Safety Study of FX-345 in Adults With Sensorineural Hearing Loss

Start date: December 15, 2022
Phase: Phase 1
Study type: Interventional

This single-blind, placebo-controlled trial will be conducted to evaluate the safety of FX-345 administered as a single intratympanic injection in adults with acquired sensorineural hearing loss. The primary objectives are to assess the local safety, systemic safety, and pharmacokinetic (PK) profile to determine systemic exposure.

NCT ID: NCT05586555 Terminated - Clinical trials for Hearing Loss, Sensorineural

A Monocentric Study Evaluating Pupillometry as an Objective Measurement for CI Fittings

PupillOM
Start date: May 2, 2023
Phase: N/A
Study type: Interventional

This trial is a monocentric, prospective and controlled study of the pupil response to detect hearing threshold and comfortable loudness of normal-hearing (NH) and CI-subjects.

NCT ID: NCT05106413 Terminated - Hearing Loss Clinical Trials

Evaluation of the Clinical Benefit of a Transmitter for Contralateral Routing of Signals (CROS)

Start date: October 26, 2021
Phase: N/A
Study type: Interventional

This study will evaluate the clinical benefit of a transmitter for contralateral routing of signals. The benefit will be evaluated in noisy environments regarding speech intelligibility when the CROS system is adjusted to different microphone settings. Additionally, data regarding overall system stability, crash reboot rate, sound quality and connectivity will be obtained over a period of time to validate the CROS system in combination with smartphone and accessories. This study is a confirmatory study.

NCT ID: NCT04882709 Terminated - Hearing Loss Clinical Trials

Compression Headphone Study

Start date: May 10, 2021
Phase: N/A
Study type: Interventional

The stimuli consist of speech in quiet, speech in noise, reverberant speech, and music recorded with different hearing aid settings, post-processed for headphone presentation and incorporated in an online sound survey. Participants will receive tablets and headphones to conduct a sound quality rating at home. The survey will involve a training session and within-subject repeated measures. Stimuli will be randomized.

NCT ID: NCT04774250 Terminated - Clinical trials for Hearing Loss, Noise-Induced

Noise-Induced Hearing Loss-Acute Exposure Treatment (UA)

PINIHL-AET
Start date: November 10, 2021
Phase: Phase 2
Study type: Interventional

The purpose of this study is to assess the safety and efficacy of zonisamide (ZNS) for the treatment of noise-induced hearing loss in adults.

NCT ID: NCT04768569 Terminated - Clinical trials for Hearing Loss, Noise-Induced

Noise-Induced Hearing Loss-Acute Exposure Treatment

PINIHL-AET
Start date: October 4, 2021
Phase: Phase 2
Study type: Interventional

The purpose of this study is to assess the safety and efficacy of zonisamide for the treatment of noise-induced hearing loss in adults.

NCT ID: NCT04276610 Terminated - Dementia Clinical Trials

Words on the Brain: Can Reading Rehabilitation for Age-Related Vision Impairment Improve Cognitive Functioning?

WOTB
Start date: May 16, 2017
Phase: N/A
Study type: Interventional

Age-related vision impairment and dementia both become more prevalent with increasing age. Research into the mechanisms of these conditions has proposed that some of their causes (e.g., macular degeneration/glaucoma and Alzheimer's disease) could be symptoms of an underlying common cause, or may be equally linked to a multifactorial context in frailty and aging. Research into sensory-cognitive aging has provided preliminary data that sensory decline may be linked to the progression of dementia through the concept of sensory deprivation. Preliminary data in hearing loss rehabilitation support the idea that improved hearing may have a beneficial effect on cognitive functioning; however, there are to date no data available to examine whether low vision rehabilitation, specifically for reading, could have an equally protective or beneficial effect on cognitive health. The present proposal aims to fill this gap.

NCT ID: NCT04242940 Terminated - Clinical trials for Bilateral Hearing Loss

Assessing Listening Effort at Different Signal-to-noise Ratios in Bone-anchored Users

Start date: February 21, 2020
Phase: N/A
Study type: Interventional

The purpose of this study is to assess listening effort during a speech-in-noise task in bone-anchored hearing systems (BAHS) users via pupillometry.

NCT ID: NCT04226456 Terminated - Tinnitus Clinical Trials

Intratympanic Administration of N-acetylcysteine for Protection of Cisplatin-induced Ototoxicity

Start date: July 10, 2021
Phase: Phase 4
Study type: Interventional

The purpose of this study is to assess the efficacity of N-acetylcystein against Cisplatin-induced ototoxicity.

NCT ID: NCT04043910 Terminated - Clinical trials for Hearing Loss, Unilateral

Functional Near Infra-Red Spectroscopic Study of Central Auditory System Cortical Functional Reorganization

SUN
Start date: April 17, 2018
Phase: N/A
Study type: Interventional

This study aims to compare the auditory cortical activity in response to monaural and binaural stimuli, measured by functional Near-Infrared Spectroscopy (fNIRS) between Single-sided Deaf (SSD) Children, and Normal-Hearing (NH) children from 5 to 16 years. Binaural audiological performance, speech skills and quality of life (QoL) will be compared between the 2 groups and links to with the cortical activity will be assessed.