Noise-Induced Hearing Loss-Acute Exposure Treatment — PINIHL-AET  

Hearing Loss, Noise-Induced Clinical Trial

Official title: Pharmaceutical Interventions for Noise-Induced Hearing Loss-Acute Exposure Treatment

Status Terminated

Clinical Trial Summary

The purpose of this study is to assess the safety and efficacy of zonisamide for the treatment of noise-induced hearing loss in adults.

Clinical Trial Description

This study is a randomized, double-blinded placebo-control trial with three parallel groups, to make use of a common control group. After being informed about the study expectations and potential risks, all individuals providing written informed consent will undergo screening to determine eligibility for study entry.

Participants who meet the eligibility requirements will be randomized in a balanced fashion into one of 3 arms:

Group 1) Zonisamide 100 milligrams (mg) pre-op + Placebo post-op; Group 2) Placebo pre- + placebo post-op; and Group 3) Zonisamide 100 mg post-op + placebo post-op ;

Related Conditions & MeSH terms

• Deafness
• Hearing Loss
• Hearing Loss, Noise-Induced

• NCT number: NCT04768569
• Study type: Interventional
• Source: Washington University School of Medicine
• Status: Terminated
• Phase: Phase 2
• Start date: October 4, 2021
• Completion date: September 29, 2023