Clinical Trials Logo
  1. Home
  2. Healthy Young Adults
  3. NCT05407259

Investigating the Inverted-U Relationship Between Cognitive Performance and Plasma Epinephrine

Healthy Young Adults Clinical Trial

Official title:
Investigating the Inverted-U Relationship Between Cognitive Performance and Plasma Epinephrine: A Registered Report of a Four-arm Crossover Randomized Controlled Trial

Clinical Trial Summary

Abstract Although acute resistance exercise has been suggested to enhance inhibitory control, a critical component of executive function, the mechanism by which acute exercise influences inhibitory control is unclear and there are methodological limitations in previous empirical studies. According to the locus coeruleus-norepinephrine (LC-NE) theory, the activity of the LC, the major releaser of NE in the brain, regulates inhibitory control. Because there is reciprocal communication between circulating epinephrine and the LC. Plasma epinephrine is chosen as the index of LC-NE activity. However, only one study in acute exercise-inhibitory control measured the plasma epinephrine. Therefore, this registered report aims to extend its findings by a four-arm crossover randomized controlled design with three different intensities, using free-weight, multiple-joint, and structural resistance exercises. Moreover, most studies showed some methodological limitations such as failing to report the process of randomization, implementing a familiarization of resistance exercise before the maximal strength test, and publishing the protocol. Without a transparent report on how the participants were allocated, the results were at risk of bias. Without a familiarization of resistance exercise, the maximal muscle strength was likely to be underestimated. Without publishing the protocol before data collection, these findings were threatened by undetected researchers' degrees of freedom such as HARKing (hypothesizing after the results are known), cherry picking, and p-hacking. This registered report will address the limitations of previous studies by incorporating cognitive and resistance exercise familiarization, transparently reporting the randomization process, and submitting it as a registered report.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05407259
Study type Interventional
Source National Taiwan Normal University
Contact Ting-Yu Lin, B.A.
Phone +886975211701
Email leo850922@gmail.com
Status Not yet recruiting
Phase N/A
Start date June 1, 2022
Completion date December 31, 2023
View Details
See also
  Status Clinical Trial Phase
Not yet recruiting NCT04391777 - Determine the Effect of the Fourth Ventricle Compression Technique on Physiological Variables N/A
Completed NCT01561716 - An Evaluation of the Energy Expenditure From Wii Fit Games N/A
Completed NCT05876663 - Effect of Kinesio Taping on Pulmonary Function and Forward Shoulder Posture FSP of Young Adults N/A
Completed NCT05515926 - Physiological Responses to Osteopathic Manipulative Techniques in Healthy Young Adults N/A
Completed NCT03628976 - Noninvasive Vagus Nerve Stimulation (VNS) for Neuromotor Adaptations N/A
Completed NCT03094520 - Cognitive Embodiment Activation by tDCS N/A
Completed NCT02376270 - Pectin, Aging and Intestinal Barrier Function Phase 4
Completed NCT02110407 - Modulation of Visual-Spatial Learning in Healthy Young Adults by tDCS N/A
Completed NCT03077529 - GOS and Microbial Fermentation in Aging N/A
Completed NCT03452761 - Effects of Exogenous Ketones in Healthy Young Adults N/A
Completed NCT06043076 - iTBS Effect on M1 Plasticity, Blood Glucose, and Cardiovascular Response N/A
Completed NCT04207528 - Campus Life Study: Harnessing Generativity Among Young Adults N/A
Completed NCT02851017 - Exergaming Versus Gym-based Exercise for Postural Control, Flow and Technology Acceptance N/A
Completed NCT04302155 - Wii Fit as Balance Assessment and Training N/A
Completed NCT02794298 - tDCS Effects on GABA Concentration and Brain Functional Connectivity in Young Adults N/A