The Effects of Short-time High-intensity Interval Training on Tissue Glucose and Fat Metabolism in Healthy Subjects and Patients With Type 2 Diabetes

Healthy Volunteers Clinical Trial

— HITPET  

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT01344928
• Other study ID #: 95/180/2010
• Status: Recruiting
• Phase: N/A
• First received: April 28, 2011
• Last updated: April 28, 2011

Study information

• Verified date: April 2011
• Source: Turku University Hospital
• Contact: n/a
• Is FDA regulated: No
• Health authority: Finland: Ethical committee of the Hospital District of the South-Western Finland
• Study type: Interventional

Clinical Trial Summary

The objectives of this study are to investigate the effects of short-time high-intensity interval training on tissue glucose and fat metabolism in healthy lean subjects and type 2 diabetic patients using modern and noninvasive imaging methods positron emission tomography (PET), magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS).

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 0
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 40 Years to 55 Years

Eligibility

Inclusion Criteria:

The healthy patients

1. Age 40-55

2. BMI 18.5-30

3. Fasting plasma glucose less than 6.1 mmol/l

4. Normal glucose tolerance test (OGTT)

The type 2 diabetic patients:

1. Age-, sex-, and BMI-matched with the study subjects in the phase 1

2. In a good treatment balance

3. Glycated haemoglobin (HbA1c) less than 7.5 mmol/l

4. Two hours glucose value in oral glucose tolerance test (OGTT) less than 10.0 mmol/l

Exclusion Criteria:

The healthy patients

1. Blood pressure > 140/90 mmHg

2. Any chronic disease

3. Any chronic medical defect or injury which hinder/interfere everyday life

4. History of anorexia nervosa or bulimia

5. History of rest or exercise-induced asthma

6. Previous use of anabolic steroids, additives or any other substrates

7. Smoking of tobacco, taking of snuffs, or use of narcotics.

8. Significant use of alcohol

9. Any other condition that in the opinion of the investigator could create a hazard to the subject safety, endanger the study procedures or interfere with the interpretation of study results

10. Presence of any ferromagnetic objects that would make MR imaging contraindicated

11. Current or history of regular and systematic exercise training

12. VO2max >40 ml/min/kg

The type 2 diabetic patients:

1. Any other chronic disease than diabetes

2. Blood pressure > 140/90 mmHg

3. Any chronic medical defect or injury which hinder/interfere everyday life

4. History of anorexia nervosa or bulimia

5. History of rest or exercise-induced asthma

6. Smoking of tobacco, taking of snuffs, or use of narcotics.

7. Any other condition that in the opinion of the investigator could create a hazard to the subject safety, endanger the study procedures or interfere with the interpretation of study results

8. Presence of any ferromagnetic objects that would make MRI imaging contraindicated

9. Current or history of regular and systematic exercise training

10. VO2max >40 ml/ min/kg

Study Design

N/A

Related Conditions & MeSH terms

• Diabetes Mellitus, Type 2
• Healthy Volunteers
• Type 2 Diabetes Mellitus

Intervention

Behavioral:
• HIT exercise intervention

• Aerobic exercise intervention

Locations

Country	Name	City	State
Finland	Turku PET Centre	Turku

Sponsors (9)

Lead Sponsor	Collaborator
Turku University Hospital	Academy of Finland, European Foundation for the Study of Diabetes, Helsinki University, Ministry of Education and Culture, Finland, Orion Farmos Research Foundation, Turku PET Centre, University of Turku, Verve Research, Oulu, Finland

Country where clinical trial is conducted

Finland,