Healthy Volunteers Clinical Trial
Official title:
Collection Of Blood Components Using Apheresis From Patients With Rheumatic or Kidney Diseases and Healthy Volunteers
This study will collect white blood cells or plasma (the liquid part of the blood), or both,
from healthy volunteers and from patients with rheumatic or kidney disorders for research
purposes. Rheumatic disorders involve abnormalities of the immune system, the body s defense
against disease. The immune system consists of white blood cells such as lymphocytes and
monocytes, which produce substances such as antibodies and cytokines. White cells and plasma
will be collected through a procedure called apheresis (described below).
Healthy volunteers and patients with confirmed or suspected rheumatic or kidney disease who
are 18 years of age or older may be eligible for this study. Patients must be participating
in a current protocol of the National Institute of Arthritis and Musculoskeletal and Skin
Diseases or the National Institute of Digestive, Diabetes and Kidney Diseases. All candidates
will be screened with a history, physical examination, and blood tests for hepatitis B and C
and HIV infection. Women of childbearing age will be tested for pregnancy. Routine blood
tests will be done in all volunteers, and in patients where needed. Pregnant women and people
who test positive for hepatitis or HIV may not participate.
Participants will undergo apheresis to collect lymphocytes, monocytes, or plasma from the
blood. For this procedure, a needle is placed in a vein in the arm. Blood flows from the vein
through a tube (catheter) into a machine that spins the blood, separating it into its
components. The required cells or plasma are extracted, and the rest of the blood, including
the red cells and platelets, is returned to the body through the same needle or through a
second needle placed in the other arm.
Cells collected from volunteers will be used in studies comparing the number and function of
similar cells from patients with rheumatic diseases, focusing on the differences in number
and function of the cells in health and disease. Components collected from patients will be
used only for studies described in the protocol in which they are currently enrolled.
...
Blood components will be collected using apheresis from normal volunteers and patients with rheumatic or kidney diseases. Mononuclear cells and plasma will be used by various investigators for research studies. ;
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