Healthy Volunteers Are Studied Clinical Trial
Official title:
Pain Sensitivity in Acute Inflammatory Pain - Gender Differences and Validity of Sensory Tests
Pain is a complex experience influenced by gender and genetics, and, by psychosocial and
sensory experiences. Pain sensitivity is thus highly variable between individuals.
In the present study we evaluate individuals´ pain perception in response to a number of
different pain stimuli in 100 healthy volunteers (50 females and 50 males).
The data will allow us to assess pain sensitivity, to predict pain responses and to
investigate gender related differences in pain perception.
A second aim is to evaluate the robustness of the different pain-tests since the tests are
repeated with an interval of 2-4 weeks.
Pain perception is affected by physiological, psychological, existential and demographic
factors.
In the present study psychophysiological, psychological, genetic and demographic components
in pain perception are evaluated in healthy volunteers (n = 100).
Psychophysical assessments following induction of a first degree burn injury (47.0 C, 420 s,
12.5 sq.cm, lower leg) include:
- pain during induction of burn injury
- thermal thresholds
- tactile thresholds
- electrical thresholds
- areas of secondary hyperalgesia
- pressure algometric assessments
- assessment of Diffuse Noxious Inhibitory Control (DNIC) efficiency
- assessment of (DNIC) using cold pressor test
Psychological assessments include:
- HADS (Hospital Anxiety and Depression Scale)
- PCS (Pain Catastrophizing Scale)
- vulnerability score
Genetics include:
- A118G SNP
Demographics include:
- gender
- height
- weight
;
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science