Healthy Volunteer Clinical Trial
Official title:
Endophenotype Characterization of a Family Psychiatric Disorder of the Bipolar Spectrum, With an Autosomal Dominant Expression
Bipolar disorder is a chronic and frequent mood pathology, that impacts on emotional and
socio-professional life of sick subjects, and also increase mortality by suicide. Suicide is
considered as a bipolar disorder result.
The main goal of this study is the endophenotype characterization from a clinical and
cognitive point of view, of a bipolar spectrum's disorder present in a family, and then
highlight a mutation of one of the genes involved is this disorder.
Heritability of bipolar disorder is now well established, but seems to be multifactorial in
most of the cases.
The use of an endophenotype characterized in a family presenting numerous bipolar sufferers
enable to reflect the expression of simpler genetic variants than those involved in the
disease, and might enable the identification of genes involved in the etiopathogenesis of
this endophenotype.
;
Endpoint Classification: Safety Study, Intervention Model: Single Group Assignment, Masking: Open Label
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