Healthy Subjects Clinical Trial
Official title:
Brain Scintigraphy in Normal Versus Kleine-Levin Syndrome Subjects
The investigators perform neuropsychological tests and brain scintigraphy in 30 healthy
subjects.
These results will be compared with data obtained out of episode in patients with
Kleine-Levin syndrome (KLS).
The investigators want to determine if brain functional imaging and cognitive abnormalities
persist during asymptomatic period in a large series of patients with KLS, and to find
predictors of these abnormalities.
3 steps in the protocol :
- Brain ECD-SPECT (marking brain perfusion in relation to brain active/hypoactive area)
superimposed on a template T1-weighted brain MRI.
- Extensive cognitive tests of executive functions, verbal memory and fluency ,
visuospatial ability and memory, reasoning abilities: spontaneous memory complaint,
Stroop Color Word Test, Trail Making Test A and B, Direct and Reverse Digit Span Test,
Letter and Semantic Fluency Test, Free and Cued Selective Reminding Test,
Rey-Osterrieth Complex Figure, Mini-Mental test, Progressive matrice of Raven (PM-38)
- KLS-inventory and face to face interview of patients and parents by neurologist for
patients. Modified KLS-inventory for healthy subjects.
Main outcome : Number of patients with persisting hypoperfused brain area (compared to
controls), location of these area, number of patients with at least -1SD in one cognitive
domain Correlation between KLS severity (disease course, number of episode, mean duration of
episodes, time incapacitated, number of symptoms) and brain perfusion and cognitive
abnormalities
;
Observational Model: Case-Crossover, Time Perspective: Cross-Sectional
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