View clinical trials related to Healthy Subjects.
Filter by:Benfotiamine pretreatment (3 days)at high dosage (1050 mg/day) prevents in healthy subjects smoking-induced vascular dysfunction assessed by ultrasound flow mediated dilatation of the brachial artery.
This study will evaluate the safety, tolerability, and pharmacokinetics (PK) of ascending doses of GAP 134 administered as 6-day continuous IV infusions to healthy subjects.
Single usage, open label study in up to 40 adult healthy males. Eligible subjects will receive a single usage of the investigational or commercial device. Retention of the radiolabeled device will be monitored using gamma scintigraphy.
AIM: Strengthening and sensorimotor training (e.g with the aim to improve balance) are widely used in rehabilitation. There is little knowledge about the best ways to combine strengthening and sensorimotor training. Therefore, the investigators want to evaluate two types of combinations in healthy participants. Interventions: - Group A: 1.) warm-up; 2.) sensorimotor training; 3.) strength training (nine sessions in four weeks) - Group B: 1.) warm-up; 2.) one strengthening exercise, followed by a sensorimotor exercise, alternating (nine sessions in four weeks) Tests (Before first training and after four weeks): - isokinetic test of knee extensors and flexors (60°/s; 120°/s; 180°/s; 240°/s.) - squat jumps and countermovement jumps - static balance test on an unstable underground (measured with accelerometer) - dynamic balance: star excursion balance test, (a) on stable ground, (b) on unstable ground. Balance tests will be performed (c) in recovered state and (d) fatigue (i.e. after a fatiguing exercise). Hypotheses 1. Group B (alternating sensorimotor and strength exercises) will improve more in the balance tests than Group A (sensorimotor first, strength afterwards). 2. Group B will improve more in the countermovement jump than Group A. 3. There will be no differences in the improvements in the strength, power and squat jump tests between the two groups.
A study in healthy volunteers to determine whether there is a drug interaction between GSK1349572 and the HIV protease inhibitors lopinavir/ritonavir and darunavir/ritonavir
A study in healthy volunteers to determine whether there is a drug interaction between GSK1349572 and etravirine
The purpose of this study is to assess the prevalence of pneumococcal stereotypes in the nasopharynx of healthy children and to describe the changes of nasopharyngeal carriage at different ages over time.
In order to evaluate the effect of CYP3A5*3 allele on the pharmacokinetics of sildenafil, udenafil, and vardenafil, the clinical trial using a single oral dose was conducted in Korean healthy male subjects whose genotype of CYP3A5 had been determined.
This open-label, multicenter study is designed to evaluate the safety, tolerability and immunogenicity of 13-valent pneumococcal conjugate vaccine in healthy children aged more than 15 months up to less than 18 years.
Study to investigate the occurence of diarrhea after either once daily or twice daily dosing for 14 days.