Healthy Men and Women Clinical Trial
Official title:
An Open-label, Randomized, 2-period Crossover Study to Compare the Pharmacokinetics of a 50-mg Dose of Liquid Etanercept Administered to Healthy Subjects by Subcutaneous Injection Using an Auto-Injector Device and Manual Injection
The purpose of the study is to compare Pharmacokinetics of liquid etanercept that is administered to healthy subjects aged 18-55 by an auto-injector device and manual injection (each subject received both injections).
This single-center, randomized, open-label, 2-period, 2-sequence, 2-treatment, crossover study in healthy men and women compared the pharmacokinetics (PK) and safety profiles of two 50-mg subcutaneous (SC) injections of etanercept liquid (in a 1.0-mL prefilled syringe): (1) using a disposable auto-injector device, and (2) using a standard manual injection. Each subject received both injections in the abdomen, separated by a washout period of 28 days. ;
Allocation: Randomized, Endpoint Classification: Pharmacokinetics Study, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Treatment
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT01706653 -
The Effects of a Polyphenol-enriched Fruit Drink on Metabolic Health
|
N/A | |
Completed |
NCT03202654 -
Effects of Corn and Coconut Oils on Lipoprotein Lipids, Insulin Sensitivity and Inflammation
|
N/A | |
Completed |
NCT02179931 -
Bioequivalence Study in Healthy Men and Women to Compare Two Pharmaceutical Formulations of Flupentixol/Melitracen (Deanxit®)
|
Phase 1 | |
Completed |
NCT03995602 -
The Effects of Dragon Fruit Consumption on Vascular Function.
|
N/A | |
Completed |
NCT01643265 -
Effect of Whey and Albumin Protein on Plasma Levels of Amino Acids
|
N/A | |
Completed |
NCT04095949 -
Absorption, Metabolism and Excretion of Artichoke Polyphenols in Healthy Individuals
|
N/A | |
Completed |
NCT03553225 -
Randomized, Double-blind, Controlled Study to Evaluate the Effect of Concord Grape Extract on Vascular Function in Healthy Men and Women
|
N/A | |
Completed |
NCT04276974 -
Effects of an Organic Plant-rich Diet on Gut Microbiome and Vascular Function (ORGAMIC Pilot Study)
|
N/A | |
Completed |
NCT01836887 -
The Effects of a Polyphenol-enriched Fruit Drink on Metabolic Health(2)
|
N/A | |
Active, not recruiting |
NCT05058157 -
Ketone Plasma Kinetics After Oral Intake of Different Ketogenic Formulae
|
N/A | |
Completed |
NCT02588534 -
Open-label Study Using 50 Mg Liquid Etanercept Subcutaneous Injection in the Thigh to Compare an Auto-injector Device and a Manual Injection in Healthy Subjects
|
Phase 1 | |
Completed |
NCT03485716 -
Metabolic Dynamics During Physical Activity
|
N/A |