The Effects of a Polyphenol-enriched Fruit Drink on Metabolic Health(2)

Healthy Men and Women Clinical Trial

Official title:

Fruit Polyphenols: Maximising Knowledge of Their Metabolic Health Benefits and Practical Applications (Phase 2)

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01836887
• Other study ID #: TSB101118 (2)
• Secondary ID: Technology Strat
• Status: Completed
• Phase: N/A
• Start date: February 2013
• Est. completion date: February 2014

Study information

• Verified date: September 2019
• Source: King's College London
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to determine whether consumption of the active product affects postprandial changes in metabolic indices, in comparison to the control product.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 22
• Est. completion date: February 2014
• Est. primary completion date: September 2013
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 20 Years to 60 Years

Eligibility

Inclusion Criteria:

• Healthy free-living men aged from 20 to 60 years old, and postmenopausal women aged from 45 to 60 years old, on the day of inclusion

• Able to understand the information sheet and comply with all the trial procedures

• Having given written consent to take part in the study prior to participation.

• Body mass index (BMI): 18.0 - 35 kg/m².

Exclusion Criteria:

• Those diagnosed with Phenylketonuria (PKU)

• Those with known or suspected food intolerances, allergies or hypersensitivity

• Women who are known to be pregnant or who are intending to become pregnant over the course of the study

• Women who are breast feeding

• Participation in another clinical trial

• Those who have donated blood within 3 months of the screening visit and participants for whom participation in this study would result in having donated more than 1500 millilitres of blood in the previous 12 months

• Those with Full Blood Counts and Liver Function test results outside of the normal range

• Pre-menopausal women due to the potential influence of cyclical changes in reproductive hormones on insulin sensitivity

• Current smokers, or reported giving up smoking within the last 6 months

• History of substance abuse or alcoholism

• Reported history of CVD, diabetes (or fasting glucose = 7.1 mmol/L), cancer, kidney, liver or bowel disease, gastrointestinal disorder or use of drug likely to alter gastrointestinal function

• Unwilling to restrict consumption of specified high polyphenol foods for 24 h before the study

• Weight loss >3kg in preceding 2 months and body mass index <18 or >35 kg/m²

• Blood pressure =160/100 mmHg

• Total cholesterol = 7.5 mmol/L; fasting triacylglycerol concentrations = 5.0 mmol/L

• Medications that may interfere with the study such as alpha-glucosidase inhibitors (e.g. acarbose), insulin-sensitising drugs (e.g. metformin, thiazolidinediones), sulfonylureas, and lipid-lowering drugs. Other medications, should be reviewed by medical representative from KCL on a case by case basis.

• Nutritional supplements that may interfere with the study such as higher dose vitamins/minerals (>200% RNI), B vitamins, Vitamin C, calcium, copper, chromium, iodine, iron, magnesium, manganese, phosphorus, potassium and zinc. Subjects already taking vitamin or minerals at a dose around 100 % or less up to 200% of the RNI, or evening primrose/algal/fish oil supplements will be asked to maintain habitual intake patterns, ensuring that they take them every day and not sporadically. They will be advised not to stop taking supplements or start taking new supplements during the course of the study.

Related Conditions & MeSH terms

• Healthy Men and Women

Intervention

Dietary Supplement:
• Very low polyphenol fruit based drink (control)

• Polyphenol-enriched fruit-based drink - low

• Polyphenol-enriched fruit-based drink - high

Locations

Country	Name	City	State
United Kingdom	Diabetes & Nutritional Sciences Division, School of Medicine, King's College London	London

Sponsors (2)

Lead Sponsor	Collaborator
King's College London	Lucozade Ribena Suntory

Country where clinical trial is conducted

United Kingdom, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Metabolic health	Postprandial metabolic response	Postprandial response (2hrs)

External Links

•   Thesis