Healthy Individuals Clinical Trial
Official title:
The Role of Serotonin in Compulsive Behavior in Humans: Underlying Brain Mechanisms
The aim of this project is to investigate: - The status of the central serotonin (5-hydroxytryptamine, 5-HT) system in compulsive behaviour and how it is affected by sub-chronic escitalopram administration - The mechanisms underlying how sub-chronic administration of escitalopram affects the central 5-HT system - How changes in cognitive performance, including the balance between habitual and goal-directed mechanisms, are affected in compulsive behaviour by boosting 5-HT function - How functional brain changes in cognitive function measured with magnetic resonance imaging relate to altered 5-HT function following escitalopram administration.
Previous studies have shown that 5-HT is strongly implicated in compulsive behaviours in experimental animals. Manipulation of 5-HT influences neuronal interactions underlying action selection. Reduced forebrain 5-HT causes perseveration and impairs goal-directed behaviour under reward but not punishment. Dysfunctional 5-HT neurotransmission has also been implicated in Obsessive-Compulsive Disorder (OCD) based on the selective efficacy of relatively high doses of selective serotonin reuptake inhibitors (SSRIs) in treating this disorder. Hitherto, it is unknown whether there is a primary defect in the serotonergic system or whether SSRIs ameliorate symptoms by modulating other brain neurotransmitter pathways. So far, only one study of central 5-HT release in OCD patients has been conducted and its methodology may be questioned. A number of behavioural and cognitive features of OCD, including endophenotype markers that appear to characterise the disorder have been determined. These include a shift in cognitive control from a goal-directed strategy to a habitual (stimulus-response, S-R) strategy, cognitive rigidity in terms of both reversal learning and attentional set-shifting, impaired response inhibition and planning, and a tendency to over-respond to spurious negative feedback in a probabilistic learning paradigm. Neural substrates of these deficits are being investigated using brain imaging methodologies based on magnetic resonance and preliminary evidence suggests an over-active medial prefrontal cortex-caudate nucleus circuits and underactive lateral prefrontal cortex-putamen circuits. However, little evidence exists that relates to the hypothesis of an over-active habit system in this disorder or to the role of serotonin in all these cognitive and behavioural deficits observed in OCD and compulsivity in general. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT06044896 -
Physiology of Body Lateralization on Regional Lung Ventilation Study
|
N/A | |
| Completed |
NCT02101801 -
Urine Drug Levels Related to Source of Water for Irrigation for Vegetable Crops Among Healthy Israeli Volunteers
|
N/A | |
| Recruiting |
NCT06101641 -
Effect of Shellac Nail Polish Application on Pulse Oximetry Measurements in Healthy Individuals
|
N/A | |
| Completed |
NCT03065283 -
Effects of Diaphragm-releasing Techniques on the Lumbar Spine and Diaphragmatic Function in Healthy Women
|
N/A | |
| Recruiting |
NCT01721811 -
Retinal Function in Relation to Transient or Chronic Challenges to Retinal Metabolism
|
N/A | |
| Completed |
NCT01211717 -
The Effects of Orally Ingesting Branched Chained Amino Acids on Delayed Onset Muscle Soreness in Diabetic Patients
|
N/A | |
| Completed |
NCT01568541 -
Fluoride Intake From Toothbrushig With Children's or Regular Toothpastes
|
N/A | |
| Completed |
NCT04941196 -
Bioequivalence Study of Anplag® 90mg (Ticagrelor) Tablet & Brilinta® 90 mg (Ticagrelor) Tablet in Healthy Adult Male Pakistani Subjects Under Fasting Condition
|
Phase 1 | |
| Completed |
NCT05541094 -
Study of Vitamin D Fortification of Milk and Oil
|
||
| Completed |
NCT05597657 -
Normal Variation of T1 Values With Cardiac Magnetic Resonance in Healthy Individuals
|
N/A | |
| Completed |
NCT03728868 -
Tolerability and Risk of Adverse Events With a Probiotic Supplement
|
N/A | |
| Recruiting |
NCT04513782 -
The Contributions of Age Related Changes in the Sound Localization Pathway to Central Hearing Loss
|
||
| Completed |
NCT05637060 -
Bioequivalence Study of Rosuvastatin Tablet
|
N/A | |
| Not yet recruiting |
NCT05110885 -
Public AttitudesTowards SMA and DMD Awareness, Newborn and Carrier Screening and Physiotherapy Practices
|
||
| Completed |
NCT01134978 -
Neural Mechanisms of the Contextual Interference Effect: A fNIRs and EEG Study
|
Phase 1 | |
| Completed |
NCT06137534 -
Upper Extremity Pattern Exercises and Respiratory Functions
|
N/A | |
| Completed |
NCT04873570 -
Bioequivalence Study of Mofest® 400mg (Moxifloxacin) Tablet With Avelox® 400mg (Moxifloxacin) Tablet in Healthy Pakistani Subjects
|
Phase 1 | |
| Enrolling by invitation |
NCT01872091 -
Analysis of Neuromuscular, Circulatory and Biomechanical Responses After Cryotherapy
|
N/A | |
| Completed |
NCT01872117 -
Assessment of Temperature by Infrared Thermography and Blood Conduction Velocity by Doppler After Applying Shortwave Diathermy and Microwave - Correlations With Cardiovascular and Hemodynamic Parameters
|
N/A | |
| Completed |
NCT02409836 -
A Study to Assess the Ingestion of Dentifrice by Children
|
N/A |