Healthy Aging Clinical Trial
Official title:
Modulating Prospective Memory in Older Adults With Noninvasive Brain Stimulation
Verified date | December 2023 |
Source | University of Bern |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Prospective memory is the ability to remember to carry out intentions with a certain delay (e.g. remember to buy stamps when passing a postal office). Prospective memory tasks require a large degree of self-initiated retrieval and in the absence of a prompt to recall, people must 'remember to remember' by their own volition. Thus, prospective memory is a challenge - especially in old age with increasing health-related prospective memory demands. Previous studies reported links between neural activity in specific brain regions and prospective memory performance. Yet, the mere occurrence of a change in brain activity in concomitance with performance of a behavioral task is not sufficient to confirm a causal relationship between the two phenomena. Therefore, this study aims to apply non-invasive brain stimulation to facilitate or inhibit activity in different brain regions presumed to be functionally associated with prospective memory. Additional to the prospective memory tasks, the investigators will implement control tasks (i.e., attention) to assess whether stimulation will specifically enhance prospective memory performance or whether other cognitive functions will be modulated additionally. It is hypothesized that stimulation will lead to changes in prospective memory functioning. Further, the investigators expect that facilitation of attentional processes might be linked to prospective memory improvements.
Status | Completed |
Enrollment | 106 |
Est. completion date | October 31, 2023 |
Est. primary completion date | October 31, 2023 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 60 Years to 80 Years |
Eligibility | Inclusion Criteria: - No cognitive impairments - Fluent in German - Right-handed - Normal or corrected-to-normal vision - Non-smokers - Written informed consent Exclusion Criteria: - Current/lifetime severe psychiatric or neurological disorder - Metal implants in the head area - Psychotropic medication - Dermatosis - Current/lifetime alcohol abuse - Magnetisable implants |
Country | Name | City | State |
---|---|---|---|
Switzerland | Universitätsklinik für Alterspsychiatrie und Psychotherapie | Bern |
Lead Sponsor | Collaborator |
---|---|
University of Bern |
Switzerland,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Other | Self-rated prospective memory | Assessed with a questionnaire (PRMQ - Prospective Retrospective Memory Questionnaire).
Comparison to performance in other tasks. |
Only at baseline session, after computer-based tasks, 10 minutes | |
Other | Self-rated metacognitive prospective memory | Assessed with a questionnaire (MPMI - Metacognitive Prospective Memory Inventory).
Comparison to performance in other tasks. |
Only at stimulation session, after intervention, 10 minutes | |
Other | Stimulation Side-Effects | Self-rating about adverse side effects during and after stimulation are assessed with a questionnaire. | Only at stimulation session, after intervention, 3 minutes | |
Other | Naturalistic prospective memory | Assessed with a behavioral task. Number of correctly retrieved naturalistic prospective memory intentions.
Change from baseline to intervention session, difference between intervention groups. |
5 minutes per session; retrieval within five days after each session | |
Other | Inhibition intra-individual coefficient of variation | Assessed with a go/no-go computer task (TAP -Test of Attentional Performance). Variability of response times (i.e., within-person fluctuation in response latency) to go-stimuli.
Change from baseline to intervention session, difference between intervention groups. |
During both sessions (for stimulation session: directly after intervention), 2 minutes | |
Other | Flexibility intra-individual coefficient of variation | Assessed with flexibility computer task (TAP -Test of Attentional Performance). Variability of response times (i.e., within-person fluctuation in response latency).
Change from baseline to intervention session, difference between intervention groups. |
During both sessions (for stimulation session: directly after intervention), 3 minutes | |
Other | Divided attention intra-individual coefficient of variation | Assessed with a computer-based task (Test of Attentional Performance). Variability of response times (i.e., within-person fluctuation in response latency).
Change from baseline to intervention session, difference between intervention groups. |
During both sessions (for stimulation session: directly after stimulation), 3 minutes 30 seconds | |
Primary | Prospective memory performance | Assessed with a computer task. Number of correct answers given to prospective memory stimuli.
Change from baseline to intervention session, difference between intervention groups. |
During both sessions (for stimulation session: during intervention), fixed to 14 minutes | |
Primary | Prospective memory reaction time | Assessed with a computer task. Reaction times of answers given to prospective memory stimuli.
Change from baseline to intervention session, difference between intervention groups. |
During both sessions (for stimulation session: during intervention), fixed to 14 minutes | |
Primary | Executive controlling functioning | Assessed with a computer task (ANT - Attentional Network Task). Interference between answers given to congruent and incongruent stimuli.
Change from baseline to intervention session, difference between intervention groups. |
During both sessions (for stimulation session: during intervention), task fixed to 6 minutes | |
Primary | Flexibility performance | Assessed with a computer task (TAP- Test of Attentional Performance). Number of correct answers.
Change from baseline to intervention session, difference between intervention groups. |
During both sessions (for stimulation session: directly after intervention), 3 minutes | |
Primary | Inhibition errors | Assessed with a computer task (Test of Attentional Performance). Sum of incorrect responses to no-go stimuli.
Change from baseline to intervention session, difference between intervention groups. |
During both sessions (for stimulation session: directly after intervention), 2 minutes | |
Primary | Divided attention misses | Assessed with a computer task (TAP - Test of Attentional Performance). Sum of missed target stimuli.
Change from baseline to intervention session, difference between intervention groups. |
During both sessions (for stimulation session: directly after intervention), 3 minutes 30 seconds | |
Primary | Flexibility reaction-time | Assessed with a computer task (TAP - Test of Attentional Performance). Mean/ median of reactions times of correct responses.
Change from baseline to intervention session, difference between intervention groups. |
During both sessions (for stimulation session: directly after intervention), 3 minutes | |
Primary | Inhibition reaction time | Assessed with a go/no-go computer task (TAP -Test of Attentional Performance). Mean/ median of reactions times to correct responses.
Change from baseline to intervention session, difference between intervention groups. |
During both sessions (for stimulation session: directly after intervention), 2 minutes | |
Primary | Divided attention reaction time | Assessed with a computer-based task (Test of Attentional Performance). Median reaction time of correct answers.
Change from baseline to intervention session, difference between intervention groups. |
During both sessions (for stimulation session: directly after stimulation), 3 minutes 30 seconds | |
Secondary | Alerting network functioning | Assessed with a computer task (ANT - Attentional Network Task). Contrasting reaction times of answers given to stimuli with alerting cues to those without alerting cues.
Change from baseline to intervention session, difference between intervention groups. |
During both sessions (for stimulation session: during intervention), task fixed to 6 minutes | |
Secondary | Orienting network functioning | Assessed with a computer task (ANT - Attentional Network Task). Contrasting reaction times of answers given to stimuli with reliable spatial cues to those without spatial cues.
Change from baseline to intervention session, difference between intervention groups. |
During both sessions (for stimulation session: during intervention), task fixed to 6 minutes | |
Secondary | Ongoing-task performance | Assessed with a computer task. Number of correctly answered ongoing task stimuli in the course of the prospective memory task.
Change from baseline to intervention session, difference between intervention groups. |
During both sessions (for stimulation session: during intervention), fixed to 14 minutes | |
Secondary | Ongoing-task reaction time | Assessed with a computer task. Mean/median response time of correct ongoing task answers in the course of the prospective memory task.
Change from baseline to intervention session, difference between intervention groups. |
During both sessions (for stimulation session: during intervention), fixed to 14 minutes | |
Secondary | Ongoing-task intra-individual coefficient of variation | Assessed with a computer task. Variability of response times (i.e., within-person fluctuation in response latency) to ongoing task stimuli in the course of the prospective memory task.
Change from baseline to intervention session, difference between intervention groups. |
During both sessions (for stimulation session: during intervention), fixed to 14 minutes |
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