Effects of Respiratory Muscle Exercises on Glucose Tolerance in Healthy Adults

Healthy Aging Clinical Trial

Official title:

Effects of Respiratory Muscle Exercises on Glucose Tolerance in Healthy Adults

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04520763
• Other study ID #: HOGTT_2020
• Status: Completed
• Phase: N/A
• Start date: August 20, 2020
• Est. completion date: April 21, 2022

Study information

• Verified date: March 2023
• Source: Swiss Federal Institute of Technology
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

To evaluate the acute effects of respiratory muscle exercises vs. a control intervention on blood glucose kinetics in healthy adults after an oral glucose tolerance test.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 42
• Est. completion date: April 21, 2022
• Est. primary completion date: April 21, 2022
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Age =18 years

• Healthy

• Non-smoking

• Body mass index (BMI): 18.5 - 29.9 kg·m-2

• Normal lung function

• Willing to adhere to study rules

Exclusion Criteria:

• Known or suspected non-compliance, drug or alcohol abuse

• Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc. of the participant

• Previous enrolment into the current study

• Intake of medications affecting metabolism, the cardiovascular or the respiratory system, or sleep

• Acute illness or chronic conditions of the gastrointestinal tract, and health conditions affecting metabolism, the cardiovascular or the respiratory system, or sleep

• Pregnancy, breastfeeding, or intention to become pregnant during the study

Related Conditions & MeSH terms

• Healthy Aging
• Healthy Diet

Intervention

Other:
• 5min respiratory muscle exercises
5 min of hyperpnea at a target intensity of 60-80% MVV 15-30min after ingestion of 75g of glucose
• 15min respiratory muscle exercises
5 min of hyperpnea at a target intensity of 60-70% MVV 15-30min after ingestion of 75g of glucose

Locations

Country	Name	City	State
Switzerland	Exercise Physiology Lab, Institute of Human Movement Sciences and Sport, ETH Zurich	Zürich	ZH

Sponsors (1)

Lead Sponsor	Collaborator
Swiss Federal Institute of Technology

Country where clinical trial is conducted

Switzerland, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Peak blood glucose concentration	Peak blood glucose concentration will be determined in the three conditions (5min or 15min respiratory muscle exercises or control).	throughout the study, an expected average of 2 weeks per participant
Primary	area under the glucose-time curve	Area under the glucose-time curve will be determined in the three conditions (5min or 15min respiratory muscle exercises or control).	throughout the study, an expected average of 2 weeks per participant