Healthy Aging Clinical Trial
Official title:
Better to Focus or to Spread? Signal Propagation and Its Relationship to Cognitive Performance in the Aging Human Brain
In the next three decades, the world's population over 60 years old is expected to more than double its size. Even in the absence of an obvious pathology (i.e., healthy aging), advancing age is typically associated with a progressive decline in cognitive performance. Although pathophysiological changes in age-related neurodegenerative disorders have received much attention over the past years, far less is known about the neural processes affecting cognition in healthy ageing. One of these postulated processes is neural dedifferentiation (i.e., a decrease in neural selectivity, by which neural representations of processed information become less univocally distinguishable), possibly accompanied by the recruitment of additional cortical areas in the healthy aging brain. To date, these processes have been extensively studied on the neural level, yet their functional significance for cognitive behaviour remains largely unclear. This project will investigate neural dedifferentiation and its relationship to cognitive performance in the healthy aging brain. To this end, the investigators will use a combination of state-of-the-art technologies including simultaneous transcranial magnetic stimulation (TMS) and high-density electroencephalography (hd-EEG) as well as diffusion tensor imaging (DTI). Perspectives include a better understanding of the relationship between neurophysiological mechanisms and cognitive performance in the healthy aging brain.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT05596474 -
Effect of Beet-root Juice and PBM Treatments on Muscle Fatigue
|
N/A | |
| Active, not recruiting |
NCT05203848 -
Community Dance Program (CDP) for Older Adults
|
Phase 1 | |
| Not yet recruiting |
NCT06455982 -
Reduced Carbohydrates + Ketogenic Supplement on Energy Metabolism
|
N/A | |
| Completed |
NCT04084457 -
Investigating the Effects of Daily Consumption of Blueberry (Poly)Phenols on Vascular Function and Cognitive Performance
|
N/A | |
| Recruiting |
NCT05006261 -
A Mobile Tai Chi Platform for Fall Prevention in Older Adults - Phase II
|
N/A | |
| Active, not recruiting |
NCT04262674 -
Non-invasive, Wearable Multi-parameter System for the Early Prediction of Cognitive Decline and Dementia in Older Adults
|
N/A | |
| Completed |
NCT02218411 -
Video-supported Group-based Otago Exercise Programme on Physical Performance in Older Adults.
|
Phase 1 | |
| Active, not recruiting |
NCT05961319 -
Smart Home Technologies for Assessing and Monitoring Frailty in Older Adults
|
||
| Completed |
NCT05213091 -
The Effect of Otago Exercises in the Elderly
|
N/A | |
| Active, not recruiting |
NCT04904068 -
Functional Neuroimaging in Parkinson's Disease
|
||
| Completed |
NCT04348162 -
Food Anthocyanins and Flavanols as a Strategy for a Healthy Ageing: Cardiovascular Health and Cognitive Performance
|
N/A | |
| Completed |
NCT05941143 -
Effect of Mindfulness on EEG Brain Activity for Cognitive and Psychological Well-being in the Elderly
|
N/A | |
| Completed |
NCT06022094 -
Effect of a Two-month Carbohydrate-restricted Diet on Energy Metabolism in a Seniors' Residence
|
N/A | |
| Active, not recruiting |
NCT06162871 -
Social Participation and Healthy Aging
|
N/A | |
| Completed |
NCT05207501 -
Effects of Different Moderate-intensity Exercise Methods on Health in the Elderly
|
N/A | |
| Recruiting |
NCT04986787 -
Novel, Individualized Brain Stimulation, Network-based Approaches to Improve Cognition
|
N/A | |
| Completed |
NCT05933798 -
China Pilot of ICOPE (Integrated Care for Older People) in Chaoyang
|
N/A | |
| Recruiting |
NCT05394363 -
Generation Victoria Cohort 2020s: A Statewide Longitudinal Cohort Study of Victorian Children and Their Parents
|
||
| Completed |
NCT04786665 -
Strawberries, Cognition, and Vascular Health
|
N/A | |
| Completed |
NCT05290571 -
Modified Otago Exercise Program on Balance Performance
|
N/A |