The Aerobic and Cognitive Training System

Healthy Aging Clinical Trial

Official title:

The Aerobic and Cognitive Training System to Improve Cognition

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04120792
• Other study ID #: UA15-011
• Status: Completed
• Phase: N/A
• Start date: May 1, 2015
• Est. completion date: November 20, 2017

Study information

• Verified date: May 2019
• Source: University of Arizona
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This study will determine the effects of simultaneous exercise and cognitive training on cognitive function in healthy older adults. Specifically, this study will compare the use of a tablet-based cognitive training system while exercising with exercise alone, cognitive training alone, and a neutral control condition on cognition.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 74
• Est. completion date: November 20, 2017
• Est. primary completion date: November 20, 2017
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 60 Years to 74 Years

Eligibility

Inclusion Criteria:

Generally healthy, age 60-74, and a written statement from their primary care physician indicating that they are able to participate in the 12-week exercise program.

Exclusion Criteria:

Subjects will be excluded from participating in the study if they express significant concerns about their memory or declines in other cognitive abilities, if they are not English speaking, or if they have histories of significant major neurological, psychiatric, or medical disorder or injury that would affect cognitive function.

Related Conditions & MeSH terms

• Healthy Aging

Intervention

Behavioral:
• Simultaneous exercise and cognitive training
Participants in this arm will engage in a 12-week intervention that combines physical exercise and cognitive tablet-based training. This intervention involves use of an exercise bicycle while engaging in cognitive tasks on a tablet computer three times per week.
• Exercise training
Participants in this arm will engage in a 12-week exercise intervention that involves use of an exercise bicycle three times per week.
• Cognitive Training
Participants in this arm will engage in a 12-week intervention that involves cognitive tablet-based training three times per week.
• Neutral video
Participants in this arm will engage in a 12-week intervention that involves watching neutral videos on a tablet computer three times per week.

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
University of Arizona

Outcome

Type	Measure	Description	Time frame	Safety issue
Other	Change from baseline in Wechsler Adult Intelligence Scale-IV Digit Span total score	A measure of working memory	Baseline, 6 weeks, 12 weeks
Other	Change from baseline in Wechsler Adult Intelligence Scale-IV Coding total score	A measure of information processing	Baseline, 6 weeks, 12 weeks
Other	Change from baseline in Wechsler Adult Intelligence Scale-IV Letter-Number Sequencing total score	A measure of working memory	Baseline, 6 weeks, 12 weeks
Other	Change from baseline in Wechsler Memory Scale-IV Paired-Associates I total score	A measure of verbal learning	Baseline, 6 weeks, 12 weeks
Other	Change from baseline in Auditory Verbal Learning Test total learning score	A test of verbal list learning	Baseline, 6 weeks, 12 weeks
Other	Change from baseline in Trail Making Test, part A total time	Tests of visuomotor tracking and complex attention	Baseline, 6 weeks, 12 weeks
Other	Change from baseline in Trail Making Test, part B total time	Tests of visuomotor tracking and complex attention	Baseline, 6 weeks, 12 weeks
Other	Change from baseline in Stroop Color and Word Test Color/Word Interference total score	A test to assess inhibition when reading color words	Baseline, 6 weeks, 12 weeks
Other	Change from baseline in Deary-Liewald Reaction Time Task Simple median response time	Tests to measure speed of information processing	Baseline, 6 weeks, 12 weeks
Other	Change from baseline in Deary-Liewald Reaction Time Task Choice median correct response time	Tests to measure speed of information processing	Baseline, 6 weeks, 12 weeks
Primary	Change from baseline in cognitive function during dual-task test at 12 weeks	Performance on serial subtraction during dual-task walking.	Baseline and 12-weeks
Secondary	Change from baseline in stride length during dual-task test	The difference between stride length in single and dual-task walking will be assessed at baseline, 6 weeks, and 12 weeks	Baseline, 6 weeks, 12 weeks
Secondary	Change from baseline in stride duration during dual-task test	The difference between stride duration in single and dual-task walking will be assessed at baseline, 6 weeks, and 12 weeks	Baseline, 6 weeks, 12 weeks
Secondary	Change from baseline in stride velocity during dual-task test	The difference between stride velocity in single and dual-task walking will be assessed at baseline, 6 weeks, and 12 weeks	Baseline, 6 weeks, 12 weeks
Secondary	Change from baseline in stride length variability during dual-task test	The difference between stride length variability (measured by coefficient of variation) in single and dual-task walking will be assessed at baseline, 6 weeks, and 12 weeks	Baseline, 6 weeks, 12 weeks
Secondary	Change from baseline in stride duration variability during dual-task test	The difference between stride duration variability (measured by coefficient of variation) in single and dual-task walking will be assessed at baseline, 6 weeks, and 12 weeks	Baseline, 6 weeks, 12 weeks
Secondary	Change from baseline in stride velocity variability during dual-task test	The difference between stride velocity variability (measured by coefficient of variation) in single and dual-task walking will be assessed at baseline, 6 weeks, and 12 weeks	Baseline, 6 weeks, 12 weeks
Secondary	Change from baseline in cognitive function during dual-task test at 6 weeks	Performance on serial subtraction during dual-task walking.	Baseline and 6-weeks