Clinical Trials Logo

Clinical Trial Summary

This is a prospective multi-center study. Bacterial isolates from hospitalized patients with CA-HRE will be compared to those from hospitalized patients with healthcare-associated HRE (HA-HRE). In addition, community spread of CRE will be determined.


Clinical Trial Description

Patients who are discharged home from the hospital and meet criteria for possible CA-HRE will be recruited. These index participants will be interviewed to determine the epidemiologic network, and will be mailed a monthly BioWipe kit to screen for ongoing HRE intestinal carriage. Contacts of the index participant will also be approached and mailed a BioWipe kit to screen for the presence of HRE and/or carbapenemase gene(s) that were present in the index patient. If this initial sample is negative, the contact is not further interviewed or tested. If the initial screening is positive for the carbapenemase gene of interest, then the contact will be asked to answer the same questions as the index patient and will receive a monthly BioWipe kit. For each positive contact, a second-generation network of contacts will be constructed, who in turn will be approached for screening. An additional subset of participants, those with CDC-defined HRE isolated during hospitalization who are not discharged home will also be included. All HRE isolates that are isolated from the patient as part of routine clinical care will be sub-cultured and shipped to the central research laboratory. A limited data set will be collected. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03924934
Study type Observational
Source University of North Carolina, Chapel Hill
Contact
Status Enrolling by invitation
Phase
Start date May 1, 2019
Completion date December 2024

See also
  Status Clinical Trial Phase
Completed NCT02400268 - Antibiotic Treatment Duration (7 vs 14 Days) Comparison in Blood Stream Infection Causes by Enterobacteriaceae Phase 3
Completed NCT03401242 - Prevalence of ESBL and CPE in French Nursing Homes
Not yet recruiting NCT03967301 - Prevention and Decolonization of Multidrug-resistant Bacteria With Probiotics N/A
Completed NCT02795949 - Study on Reduced Antibiotic Treatment vs Broad Spectrum Betalactam in Patients With Bacteremia by Enterobacteriaceae Phase 3
Completed NCT00573235 - Epidemiology of Community - Associated Extended-spectrum Beta-lactamases (ESBL) Producing Escherichia Coli
Recruiting NCT00404625 - Infections Caused by ESbL-Producing Enterobacteriaceae in Italy N/A
Completed NCT00573521 - Risk Factors for Piperacillin/Tazobactam Resistance in Extended-Spectrum Beta-Lactamase (ESBL) Producing Organisms
Recruiting NCT03671967 - PipEracillin Tazobactam Versus mERoPENem for Treatment of Bloodstream Infections Caused by Cephalosporin-resistant Enterobacteriaceae (PETERPEN) Phase 4
Completed NCT03477084 - Understanding and Modeling Reservoirs, Vehicles and Transmission of ESBL-producing Enterobacteriaceae in the Community and Long Term Care Facilities
Not yet recruiting NCT05632315 - PMT for MDRO Decolonization Phase 2
Withdrawn NCT03527056 - Pilot Study Using Oral Capsule FMT to Decolonize GI CRE Early Phase 1
Completed NCT00826670 - Enterobacteriaceae Producing Extended-spectrum β-lactamases (ESBL) Decolonization Study Phase 4
Not yet recruiting NCT04903886 - Intensive Care Unit Acquired Infections in Patients Colonized With Extended Spectrum Enterobacteriaceae
Completed NCT02482051 - Ultra Rapid Culture Independent Detection of High-Priority Carbapenem Resistant Enterobacteriaceae Directly From Blood
Recruiting NCT00894036 - The Burden and Genetic Variability of Extended-Spectrum ß-Lactamase (ESBL) - Producing Pathogens in Swiss Children N/A
Suspended NCT05355350 - PipEracillin/Tazobactam Versus mERoPENem for Treatment of AmpC Producing Blood Stream Infections Phase 4
Recruiting NCT05516433 - Effect of Imipenem and Meropenem on the Digestive Microbiota and the Emergence and Carriage of Multidrug-resistant Bacteria
Recruiting NCT02450942 - 18F-FDS PET/CT in Healthy Volunteers and Patients With Suspected Infection Early Phase 1
Recruiting NCT05035342 - Fecal Transplantation to Eradicate Colonizing Emergent Superbugs Phase 3
Not yet recruiting NCT03411590 - The Effect of Fortified Growing-up Milk on Growth and Micronutrient Status of Nigerian Toddlers N/A