Enterobacteriaceae Infections Clinical Trial
Official title:
Investigation of the Prevalence of Fecal Carriage of Extended Spectrum bêta-lactamase Producing Enterobacteriaceae (ESBL) and Carbapenemase Producing Enterobacteriaceae (CPE) in Nursing Homes
CARBEHPAD is a multicentric randomized prevalence study aiming to assess the frequency of
Enterobacteriaceae (ESLB) and carbapenemase producing Enterobacteriaceae (CPE) carriage in
Pays de la Loire nursing homes.
A sample of 50 nursing homes (NH) in Pays de la Loire will be randomly selected for
inclusion, and a sample of 1/3 of residents of these NH will be screened for ESBL and/or CPE
fecal carriage. Epidemiological data on each resident will be collected to identify risk
factors for such carriage.
The Pays de la Loire region is impacted by 2 main CPE outbreaks in the 2 major university
hospitals in this region. A sample of 50 nursing homes (NH) in Pays de la Loire region
(France) will be randomly selected for inclusion in CARBEHPAD study. NH directors will be
contacted for agreement for inclusion in CARBEHPAD study. In each of the included NH, a
sample of one third of residents will be randomly selected for inclusion. Upon agreement,
each resident included will be screened through endorectal swabbing for ESBL and/or CPE
carriage.
Epidemiological data will be collected for each resident regarding demographic data, risk
factors for ESBL and/or CPE carriage, comorbidities. These data collected in the NH will be
completed with data collection from national NH database regarding: previous hospitalization,
treatments (including antibiotics), surgery.
Data on infection control and prevention will be collected in each NH to assess cross
transmission of resistant bacteria in these settings.
Comparison of isolated strains will be performed to assess clonal dissemination of these
resistant Enterobacteriaceae in NH. Data regarding infection control and prevention in each
included NH will be collected aswell.
An ESBL/CPE carrier status has no impact on medical care in NH regarding French
recommendations on management of such resistant microorganisms.
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