Health Clinical Trial
Official title:
Relative Bioavailability of Different n-3 Fatty Acid Formulations in Humans
The aim of this study is to examine differences in short term bioavailability between four n-3 FA formulations in healthy males.
The long-chain n-3 fatty acids (n-3 FAs) eicosapentaenoic acid (EPA) and docosahexaenoic
acid (DHA) are known to positively affect the lipid profile, vascular tone and blood
coagulation. Moreover, EPA and DHA possess anti-inflammatory effects and play a central role
in the functioning of the brain and central nervous system. Therefore, an increased EPA and
DHA intake is highly recommend. However, it is unknown whether different chemical
formulations of EPA + DHA rich supplements (re-esterified triglycerides, ethyl-esters,
phospholipids) have identical bioavailability. The objective of this study is to examine
differences in short term bioavailability between four n-3 FA formulations:
- Supplement 1: EPA+DHA as re-esterified triglycerides (rTGs) from fish-oil uncoated
capsules
- Supplement 2: EPA+DHA as rTGs from fish-oil in gastric acid resistant (coated) capsules
(GArTG)
- Supplement 3: EPA+DHA as ethylesters (EE) from fish-oil uncoated capsules
- Supplement 4: DHA+EPA as phospholipids from krill-oil, uncoated capsules (KPL)
The study preparations are certificated supplements and available on the market.
There are no comparative investigations, which analyzed the bioavailability of these four
n-3 FA formulations in a similar design.
;
Allocation: Randomized, Endpoint Classification: Bio-availability Study, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Prevention
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