Health Clinical Trial
Official title:
Effects of Tolterodine, a Non-Specific Muscarinic Antagonist, on Gastrointestinal Transit in Healthy Subjects
The muscarinic antagonist tolterodine is widely used treat urinary urge incontinence. Though acteylcholine is the primary excitatory neurotransmitter in the gastrointestinal tract, the phase III trials suggest that tolterodine infrequently causes constipation. Therefore, the objectives of this study are to assess if tolterodine affects the speed at which food travels through the stomach, intestines and colon (i.e., gastrointestinal and colonic transit) in healthy subjects.
The specific aims of this study are to test the hypotheses that the non-specific muscarinic antagonist tolterodine will not:- i) delay colonic transit and the proximal colonic emptying rate; ii) delay gastric emptying; nor iii) delay small intestinal transit compared to placebo in healthy subjects. ;
Allocation: Randomized, Endpoint Classification: Pharmacokinetics/Dynamics Study, Intervention Model: Parallel Assignment, Masking: Double-Blind, Primary Purpose: Treatment
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT03601715 -
Analysis of Human Tissue Temperature After Application of Therapeutic Modalities.
|
N/A | |
| Completed |
NCT02145273 -
Healthy Moms-Healthy Kids: Reducing Maternal Depression for Better Outcomes in Head Start Children
|
N/A | |
| Recruiting |
NCT01985152 -
A Phase Ⅰa Study of Azilsartan Trimethylethanolamine in Healthy Volunteers
|
Phase 1 | |
| Active, not recruiting |
NCT00970398 -
Effect of an Infant Formula on Infant Growth, Health and Immune Functions
|
N/A | |
| Recruiting |
NCT06060379 -
Giochiamo 626 - Gaming for Health and Safety in Workplaces
|
N/A | |
| Completed |
NCT04998266 -
Evaluation of Physical Capacities Within the Company and Effect of a Personalized Versus Traditional Training Program on the Quality of Life of Sedentary Employees
|
N/A | |
| Completed |
NCT01214278 -
Bioavailability of Different n-3 Fatty Acid Formulations
|
Phase 4 | |
| Recruiting |
NCT06157346 -
Characteristics of Intestinal Bacteria and Their Effects on Growth and Immune Function in Children at High Altitude
|
||
| Completed |
NCT01057368 -
The Effects of Well-being Interventions on Affect, Attention, Sleep, Social Stress and Pain Regulation
|
N/A | |
| Completed |
NCT01216605 -
Oxytocin and Emotion Recognition
|
Phase 4 | |
| Completed |
NCT02287441 -
Feasibility Study to Increase Vegetable Consumption
|
N/A | |
| Recruiting |
NCT02132741 -
Optical Coherence Tomography And NEphropathy: The OCTANE Study
|
||
| Completed |
NCT01762553 -
TEA for Families and Children: A Randomized Intervention Trial
|
N/A | |
| Completed |
NCT01123772 -
Phase I Dose-Escalation Study to Evaluate Tolerability, Safety & PK of INO-8875 in Healthy Older-Adult Volunteers
|
Phase 1 | |
| Completed |
NCT03527654 -
SER Hispano Longitudinal Study
|
||
| Completed |
NCT03414346 -
Analysis of the Effects on Human Tissues After Application of Therapeutic Modalities.
|
N/A | |
| Completed |
NCT02116283 -
Mobile Sensing of Smoking Behavior
|
N/A | |
| Completed |
NCT05104385 -
Hacettepe University COVID-19 Vaccinated's Health Cohort- Students of Health Sciences
|
||
| Completed |
NCT00962195 -
The Effect of Purple Sweet Potato (PSP)-Juice on Liver Enzymes and Blood Pressure
|
N/A | |
| Completed |
NCT03788109 -
Relationship Between Gastric Accommodation, TLESRs and Reflux in HV and in GERD With or Without Overlapping Dyspepsia
|
N/A |