Health Behavior Clinical Trial
Official title:
The Investigation of Lifestyle and Genetics in Super Lean Subjects That Keep Them Resistant to Weight Gain
NCT number | NCT03221322 |
Other study ID # | 0060 |
Secondary ID | |
Status | Recruiting |
Phase | |
First received | |
Last updated | |
Start date | April 6, 2017 |
Est. completion date | December 31, 2025 |
Obesity is the 5th leading cause of global death, and is major risk factors for many chronic diseases, such as type 2 diabetes, cardiovascular diseases, hypertension and cancer. Obesity is caused by an imbalance between energy intake and energy expenditure, and it is widely agreed to be a consequence of a gene by environment interaction. Although on average obesity rates are increasing, the shape of the distribution of adiposity is changing: it is becoming more right skewed. This is because there is a population of very lean subjects that has remained almost unchanged by the epidemic. The investigators have called these very lean individuals that are resistant to the epidemic and sustain a BMI < 18.5 kg/m2 'super lean' subjects. We have very little understanding of the lifestyles of these individuals and how they are able to maintain their super lean phenotype, and whether the basis of their leanness is primarily genetics.
Status | Recruiting |
Enrollment | 300 |
Est. completion date | December 31, 2025 |
Est. primary completion date | December 31, 2025 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 20 Years to 40 Years |
Eligibility | Inclusion Criteria: - control: BMI 20-25 kg/m2, healthy, age 20-40 years old superlean: BMI 15-18 kg/m2, healthy, with no eating disorders and diabetes, age 20-40 years old Exclusion Criteria: - Pregnant women and women in lactation Subjects are suffering from eating disorders or diabetes. |
Country | Name | City | State |
---|---|---|---|
China | Institute of Genetics and Developmental Biology | Beijing |
Lead Sponsor | Collaborator |
---|---|
Chinese Academy of Medical Sciences |
China,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Anthropometric measurements of participants in both control and superlean groups | Height, waist and hip circumferences (cm) and body composition will be measured on arrival. | Through study completion, an average of 2 years | |
Primary | Demographic characteristics of all participants in both control and superlean groups | Life style questionnaire filled out on arrival. | Through study completion, an average of 2 years |
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