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Clinical Trial Details — Status: Recruiting

Administrative data

NCT number NCT03221322
Other study ID # 0060
Secondary ID
Status Recruiting
Phase
First received
Last updated
Start date April 6, 2017
Est. completion date December 31, 2025

Study information

Verified date July 2022
Source Chinese Academy of Medical Sciences
Contact John Speakman, PhD
Phone +86-10-64807042
Email j.speakman@abdn.ac.uk
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Obesity is the 5th leading cause of global death, and is major risk factors for many chronic diseases, such as type 2 diabetes, cardiovascular diseases, hypertension and cancer. Obesity is caused by an imbalance between energy intake and energy expenditure, and it is widely agreed to be a consequence of a gene by environment interaction. Although on average obesity rates are increasing, the shape of the distribution of adiposity is changing: it is becoming more right skewed. This is because there is a population of very lean subjects that has remained almost unchanged by the epidemic. The investigators have called these very lean individuals that are resistant to the epidemic and sustain a BMI < 18.5 kg/m2 'super lean' subjects. We have very little understanding of the lifestyles of these individuals and how they are able to maintain their super lean phenotype, and whether the basis of their leanness is primarily genetics.


Description:

In this study, the investigators will recruit a sample of 150 super lean healthy volunteers with a BMI >15 and < 18.5 kg/m2 aged 20-40 years, in parallel with an age matched group of 150 healthy subjects with a BMI ≥22 and < 25 kg/m2 as the control group. The investigators will screen out any individuals with eating disorders. In both groups, the investigators will study their lifestyles in particular focusing on their physical activity patterns and their food intake choices (monitored via food intake diaries and supported by metabolomics analyses of their urine to detect biomarkers of different food groups). Saliva samples will be collected for genotyping. The investigators will SNP genotype the individuals for 30 known polymorphic loci previously linked to obesity to establish if they have a particular genetic profile linked to their lean phenotype.


Recruitment information / eligibility

Status Recruiting
Enrollment 300
Est. completion date December 31, 2025
Est. primary completion date December 31, 2025
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 20 Years to 40 Years
Eligibility Inclusion Criteria: - control: BMI 20-25 kg/m2, healthy, age 20-40 years old superlean: BMI 15-18 kg/m2, healthy, with no eating disorders and diabetes, age 20-40 years old Exclusion Criteria: - Pregnant women and women in lactation Subjects are suffering from eating disorders or diabetes.

Study Design


Related Conditions & MeSH terms


Intervention

Behavioral:
Superlean
Behavioural data will be collected on all subjects in either control group or superlean group. Blood or saliva samples will be collected for DNA extraction and genotyping.

Locations

Country Name City State
China Institute of Genetics and Developmental Biology Beijing

Sponsors (1)

Lead Sponsor Collaborator
Chinese Academy of Medical Sciences

Country where clinical trial is conducted

China, 

Outcome

Type Measure Description Time frame Safety issue
Primary Anthropometric measurements of participants in both control and superlean groups Height, waist and hip circumferences (cm) and body composition will be measured on arrival. Through study completion, an average of 2 years
Primary Demographic characteristics of all participants in both control and superlean groups Life style questionnaire filled out on arrival. Through study completion, an average of 2 years
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