Head Trauma Clinical Trial
Official title:
QuickBrain MRI for Acute Pediatric Head Trauma
NCT number | NCT03291964 |
Other study ID # | 17254 |
Secondary ID | |
Status | Completed |
Phase | |
First received | |
Last updated | |
Start date | September 3, 2017 |
Est. completion date | December 1, 2019 |
Verified date | April 2022 |
Source | Oregon Health and Science University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
Pediatric head trauma is a leading cause of morbidity and mortality for children/adolescents. The current standard of care regarding imaging modality when concerned for an acute head injury is CT. This exposes children to radiation that may predispose to future malignancy. Rapid MRI is a test that eliminates radiation and has expanded uses in multiple other areas. This study is evaluating it for pediatric acute head trauma.
Status | Completed |
Enrollment | 76 |
Est. completion date | December 1, 2019 |
Est. primary completion date | August 1, 2019 |
Accepts healthy volunteers | |
Gender | All |
Age group | 0 Years to 14 Years |
Eligibility | Inclusion Criteria: 1. The patient presents to the pediatric emergency department or trauma system at OHSU or is a trauma system transfer patient to OHSU 2. Age 0-14 years. 3. Being evaluated for a traumatic head injury and attending physician decides to obtain a head CT. 4. Clinically stable for additional testing: provider deems it safe to obtain a QbMRI in the ED without deep sedation Exclusion Criteria: 1. Subject is from outside hospital and head CT was performed greater than 6 hours prior 2. Subject is from outside hospital and initial head CT is not in our imaging system for review 3. History of intracranial surgery 4. History of metallic implants making MRI contraindicated 5. Decompressive surgery prior to QbMRI |
Country | Name | City | State |
---|---|---|---|
United States | OHSU | Portland | Oregon |
Lead Sponsor | Collaborator |
---|---|
Oregon Health and Science University |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Sensitivity: Percentage of MRIs Correctly Identifying Clinically Important Intracranial Injury (True Positives) | Sensitivity of Rapid MRI for detection of a clinically important intracranial injury: Percentage of MRIs identifying clinically important intracranial injury. Sensitivity was calculated as the number of true positives divided by "true positive plus false negative". True positive was defined based on meeting clinical criteria for a clinically important TBI and if the imaging found the injury. | within 6 hours from the initial head CT | |
Secondary | Time From Order to Obtaining MRI | minutes | During initial ER stay within 3 hours from time of entry to the ER | |
Secondary | Need for Anxiolysis Medication (Defined as Benzodiazepines for Imaging Indication) | Number of patients requiring medication to obtain imaging | During initial ER stay within 3 hours from time of entry to the ER |
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