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NCT06420219 Clinical Trial

An Integrative Multi-Omic Characterization of Head and Neck Carcinogenesis, Progression and Recurrence

Head and Neck Carcinoma Clinical Trial

Official title:
An Integrative Multi-Omic Characterization of Head and Neck Carcinogenesis, Progression and Recurrence

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT06420219
Other study ID # 7H-23-4
Secondary ID NCI-2024-015597H
Status Recruiting
Phase
First received
Last updated
Start date March 25, 2024
Est. completion date March 25, 2029

Study information
Verified date May 2024
Source University of Southern California
Contact Sandy Tran, MS
Phone 323-865-0451
Email sandy.tran@med.usc.edu
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

This study evaluates the cell and biomarkers associated with the aggressive behavior of cancer.

Description:

PRIMARY OBJECTIVE: I. High-resolution single-cell profiling of Cancer-associated fibroblasts (CAFs) in Human papillomavirus (HPV)+ Oropharyngeal Squamous Cell Carcinoma (OPSCC) and metastatic lymph nodes. OUTLINE: This is an observational study. Patients undergo photography, blood sample collection, tissue collection and have their medical records reviewed on study.

Recruitment information / eligibility
Status Recruiting
Enrollment 50
Est. completion date March 25, 2029
Est. primary completion date March 25, 2028
Accepts healthy volunteers No
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria: - Diagnosis/disease status: New diagnosis of head and neck cancer - Allowable type and amount of prior therapy: No prior treatment - Age = 18 years. - Ability to understand and the willingness to sign a written informed consent. Exclusion Criteria: - Patients who have had treatment of head and neck cancer

Study Design

Related Conditions & MeSH terms

Intervention

Other:
• Non-Interventional Study
Non-interventional study

Locations
Country Name City State
United States USC / Norris Comprehensive Cancer Center Los Angeles California

Sponsors (2)
Lead Sponsor Collaborator
University of Southern California National Cancer Institute (NCI)

Country where clinical trial is conducted

United States, 

Outcome
Type Measure Description Time frame Safety issue
Primary Overall survival Up to 5 years
Primary Disease free survival Up to 5 years
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