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Intraoperative Identification and Stimulation of the Glossopharyngeal Nerve

Head and Neck Cancer Clinical Trial

Official title:
Intraoperative Identification and Stimulation of the Glossopharyngeal Nerve

Clinical Trial Summary

Published data suggest that the glossopharyngeal nerve innervates pharyngeal musculature important for maintenance of upper airway patency. The investigators propose a study examining the anatomic variation of the glossopharyngeal nerve and the effect of electrical stimulation on muscle recruitment and upper airway patency.

Clinical Trial Description

This is a single-arm physiology study. Consenting patients undergoing parapharyngeal space (PPS) surgery for tumor extirpation will undergo dissection of the glossopharyngeal nerve branches to the stylopharyngeus and pharyngeal constrictor muscles. Fine-wire electrodes will be placed on these nerve branches. For each patient, if the target nerve branches can be identified and electrodes successfully placed, they will additionally undergo drug-induced sleep endoscopy (DISE) immediately following PPS surgery. Per routine care, an incision is made across the neck to provide surgeons access to parapharyngeal space for tumor extirpation. During this dissection, the branch(es) of the glossopharyngeal nerve innervating the stylopharyngeus (SP) and pharyngeal constrictor (PC) muscles are exposed. For this study, measurements and photos/videos of the nerve will be taken. A fine-wire electrode will be placed on either or both successfully identified nerves and stimulated to assess muscle activation and changes in upper airway patency. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05754216
Study type Interventional
Source Vanderbilt University Medical Center
Contact
Status Enrolling by invitation
Phase N/A
Start date December 2024
Completion date March 2027
View Details
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