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Clinical Trial Summary

Hand osteoarthritis is one of the most common arthritis, resulting in pain in finger and thumb base joints. The disease is characterized by pain and stiffness of the affected joints and is the most common cause of disability in aged people. Currently limited therapy options are available. Synovial inflammation is involved in the joint pain. Iguratimod is a small disease-modifying compound that can influence anti-inflammatory pathways in models of rheumatoid arthritis. It has an anabolic effect on the bone metabolism of infected joint by osteoclastogenesis inhibition and osteoblast differentiation. The investigators hypothesize that Iguratimod will alleviate pain of patient with inflammatory hand osteoarthritis, and that a beneficial effect of Iguratimod on pain will be accompanied by a decrease of synovial inflammation.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT05216757
Study type Interventional
Source Peking University People's Hospital
Contact
Status Not yet recruiting
Phase Phase 2/Phase 3
Start date March 2022
Completion date December 2024

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