Hand Osteoarthritis Clinical Trial
Official title:
Symptomatic Effects of Long-term Crystalline Glucosamine Sulfate Therapy in Hand Osteoarthritis: a Comparative Retrospective Study
The objective of this study is to retrospectively evaluate the symptomatic effects of crystalline glucosamine sulfate (GS), prescribed for the actually approved indication of knee OA, in addition to conventional therapy, in comparison to the conventional therapy alone in patients with primary hand osteoarthritis (HOA).This is a 6-months retrospective comparative study including patients with concomitant knee and primary HOA, according to the ACR criteria. To be eligible the patients had to present clinical symptoms of hand OA for at least 3 months, defined as global hand pain score superior to 40 mm on a 0-100 Visual Analogue Scale (VAS) and a Functional Index for Hand Osteoarthritis (FIHOA) score of at least 6. Furthermore, the patients have had a radiographic evidence of HOA within the previous 6 months with a Kellgren-Lawrence score of II-III. The participants are stratified into two groups based on whether or not crystalline GS at the daily dose of 1500 mg was added to the conventional therapy for HOA, including exercise, acetaminophen and non steroidal anti-inflammatory drugs (NSAIDs) or cyclo-oxygenase (COX)-2 inhibitors. Primary outcome measures are the difference between the two groups in the change of VAS pain and in the FIHOA, from baseline after 6 months. Secondary outcomes were health assessment questionnaire (HAQ), medical outcomes study 36-item short form (SF-36) and symptomatic drugs consumption.
n/a
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT01910116 -
Efficacy of Shinabro in Hand Osteoarthritis
|
Phase 2/Phase 3 | |
Completed |
NCT02612233 -
Pain Management in Osteoarthritis Using the Centrally Acting Analgesics Duloxetine and Pregabalin
|
Phase 4 | |
Completed |
NCT01249391 -
Splinting to Treat Hand Osteoarthritis
|
Phase 2 | |
Recruiting |
NCT04402047 -
Electroacupuncture vs Topical Diclofenac Sodium Gel for Patients With Hand Osteoarthritis
|
N/A | |
Completed |
NCT04576403 -
Heated Mittens for Patients With Hand Osteoarthritis
|
N/A | |
Completed |
NCT02528630 -
Progressive Strength in Hand Osteoarthritis
|
Phase 4 | |
Completed |
NCT01874067 -
C-GLOVES: the Effectiveness of Compression Gloves in Arthritis
|
||
Suspended |
NCT03703934 -
Central Pain Mechanisms in Patients With Hand-Osteoarthritis, Psoriatic Arthritis and Healthy Controls
|
||
Completed |
NCT04585113 -
Diagnostic Accuracy of Dual-energy CT
|
||
Completed |
NCT05568875 -
Happy Hands - an E-self-management Intervention for People With Hand Osteoarthritis
|
N/A | |
Completed |
NCT03693833 -
CBD Treatment in Hand Osteoarthritis and Psoriatic Arthritis.
|
Phase 2 | |
Completed |
NCT05150171 -
Happy Hands E-self-management Pilot Study
|
N/A | |
Completed |
NCT02667145 -
Assistive Device for Hand Osteoarthritis
|
N/A | |
Completed |
NCT02477059 -
Effect of the Interleukin-6 Receptor Antagonist Tocilizumab in Patients With Hand Osteoarthritis
|
Phase 3 | |
Recruiting |
NCT04611347 -
Topical CBD in Joint Arthritis
|
Phase 2 | |
Completed |
NCT04036929 -
Can we Use Estrogen-containing Therapy to Improve Pain in Women After Menopause With Hand Osteoarthritis?
|
N/A | |
Completed |
NCT03919279 -
Treatment of Erosive Digital Osteoarthritis by Transcutaneous Auricular Nerve Stimulation
|
N/A | |
Recruiting |
NCT06329219 -
Water-filtered Infrared-A Radiation in Patients With Hand Osteoarthritis
|
N/A | |
Not yet recruiting |
NCT05216757 -
Efficacy and Safety of Iguratimod in Patients With Hand Osteoarthritis (ESIGO)
|
Phase 2/Phase 3 | |
Completed |
NCT02771860 -
RANKL-blockade for the Treatment of Erosive Osteoarthritis (OA) of Interphalangeal Finger Joints
|
Phase 2 |