Hand Deformities Clinical Trial
Official title:
BION Implantable Microstimulator
The study looks at a new treatment for wrist and finger contractures -- a condition where the affected hand is in a "closed" position, with the wrist and fingers stiff and difficult to move from that position. We want to study if stimulation of wrist and finger muscles using an implanted neuromuscular stimulator (BION) will be more or less effective than doing passive exercises of the affected hand to improve the range of movement at wrist and finger joints. Subjects of this study will be randomized into one of three groups: one doing passive movement therapy; one receiving surface stimulation (electrical stimulation with electrodes on the skin of the arm) and one doing BION® therapy. The passive movement group will do therapy for 12 weeks. Subjects in either stimulation group will receive stimulation for 6 weeks and then only passive therapy for 6 weeks.
Status | Completed |
Enrollment | 30 |
Est. completion date | December 2008 |
Est. primary completion date | December 2008 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 18 Years to 85 Years |
Eligibility |
Inclusion Criteria: 1. Diagnosis of hemiplegic stroke 6 months to 20 years prior to enrollment in this study; 2. Paresis of extensors in the forearm; 3. Demonstrable restriction of hand or wrist mobility (i.e. significant stretch response, defined as a 2+ or greater on the Ashworth scale, can be elicited in the finger or wrist flexor muscles, and the patient's resting hand posture is flexed when the patient is standing with the upper arm pendant and the elbow flexed); 4. Age 18 years or older; 5. Stable pattern of pain-medication use for at least one month prior to enrollment; 6. Medically stable; 7. Able to travel to the testing center; 8. Mentally capable to understand and carry out the procedures and communicate concerns; and 9. Able and willing to participate and provide informed consent. 10. Ability to bring the wrist into neutral posture and the MCP joints into 30 degrees of flexion Exclusion Criteria: 1. Pregnant, nursing, or planning to become pregnant within the study timeframe; 2. Presence of electronic implants (e.g., cardiac pacemaker, cochlear implant, neurostimulator, etc.); 3. Presence of metallic implants, such as artificial elbow implants or metal screws, in the immediate field of the magnetic coil (on the arm between the fingers and the shoulder). 4. Use of electrical stimulation for treatment of relevant extensor muscles in the past month; 5. Inability to recruit muscles through surface electrical stimulation because of excessive adipose tissue; 6. Presence of other unrelated hand or wrist pathologies; participating in other treatments including active physical therapy or drug therapy that affect their hand or wrist. 7. Severe hemineglect; and 8. Cancer or other serious illness, including a disease other than stroke resulting in motor dysfunction. |
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
Country | Name | City | State |
---|---|---|---|
United States | Rancho Los Angeles National Rehabilitation Center | Downey | California |
Lead Sponsor | Collaborator |
---|---|
University of Southern California |
United States,
Loeb GE, Richmond FJ, Baker LL. The BION devices: injectable interfaces with peripheral nerves and muscles. Neurosurg Focus. 2006 May 15;20(5):E2. Review. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | passive Range of Motion, active Range of Motion, Rancho Arm Function Scale, Fugl Meyer Function Scale | baseline, 2 weeks, 4 weeks and 6 weeks | No |