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A Comparative Study Between Concomitant Versus Load Therapy in Eradication of Helicobacter Pylori Infection

H. Pylori Infection Clinical Trial

Official title:
A Comparative Study Between Concomitant Versus Load Therapy in Eradication of Helicobacter Pylori Infection

Clinical Trial Summary

All patients who presented with epigastric pain and dyspeptic symptoms will undergo endoscopic gastric biopsies. The patients will be subjected to: Full history taking, clinical examination, liver function tests, renal function tests, CBC, INR, abdominal ultrasonography. About 200 patients diagnosed to have H. pylori by infection by microscopically examined, endoscopic gastric biopsies will be enrolled in our study. All available formalin fixed and paraffin embedded tissue blocks of gastric endoscopic biopsies will be resectioned and stained with Haematoxylin and Eosin. Modified Giemsa stain, and Alcian blue/ PAS stain will be used for verification of Helicobacter pylori and demonstration of intestinal metaplasia respectively. Biopsies will be classified using the Updated Sydney system of classification of gastritis

Clinical Trial Description

The patients will be randomized (closed envelopes) into one of two groups: 1. patients will receive concomitant therapy comprising of pantoprazole (40 mg twice daily), amoxicillin (1 gm twice a day), clarithromycin (500 mg twice a day) and metronidazole (500 mg twice a day) for 2 weeks. 2. patients will receive LOAD therapy comprising of levofloxacin (250 mg with breakfast), omeprazole (40 mg before breakfast), nitazoxanide (Alina) (500 mg twice daily with meals) and doxycycline (100 mg at dinner) for 10 days. H. Pylori eradication will be confirmed by H. Pylori stool antigen testing at least 4 weeks after cessation of antibiotic therapy with stoppage of PPI therapy at least one to two weeks. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06050824
Study type Interventional
Source Helwan University
Contact
Status Completed
Phase Phase 4
Start date July 21, 2022
Completion date July 19, 2023
View Details
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