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Eradication Efficacy and Safety of Two Rescue Treatments for Helicobacter Pylori Infection

H. Pylori Infection Clinical Trial

Official title:
Eradication Efficacy and Safety of High-dose Dual Therapy Compared With Furazolidone-based Quadruple Therapy as a Rescue Treatment for Helicobacter Pylori Infection: a Randomized Controlled Trial

Clinical Trial Summary

The aim of this study was to evaluate the efficacy and safety of high-dose dual therapy compared with furazolidone-based quadruple therapy as a rescue treatment for helicobacter pylori infection.

Clinical Trial Description

Helicobacter pylori (H. pylori) infection is common worldwide and is strongly associated with peptic ulcer and gastric cancer. The eradication rate of H. pylori treatment is limited in the recent years although standard first-line therapy is used. There is a growing antibiotic resistance due to antibiotic consumption for other infections. The failure of first-line therapy for H. pylori can significantly limit the efficacy of the subsequent rescue therapies. H. pylori resistance to amoxicillin (AMO), both primary and acquired, have been reported to be uncommon. The bactericidal effect of AMO against H. pylori is pH- and time- dependent with a sustaining higher intragastric pH. Thus, the therapy consisting of high-dose PPI and AMO may have advantage over the currently recommended furazolidone-based quadruple therapy. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05176821
Study type Interventional
Source Shanghai Zhongshan Hospital
Contact Jie Chen, MD
Phone 8613764633539
Email chen.jie5@zs-hospital.sh.cn
Status Recruiting
Phase N/A
Start date January 1, 2021
Completion date December 31, 2022
View Details
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