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Gynecologic Cancer clinical trials

View clinical trials related to Gynecologic Cancer.

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NCT ID: NCT06432478 Recruiting - Endometrial Cancer Clinical Trials

3D Printed Custom Applicators for HDR BT (DISCO)

Start date: November 24, 2023
Phase: N/A
Study type: Interventional

Intracavitary brachytherapy for gynaecological cancer currently use cylinder-type applicators or custom wax moulds to place a radioactive source in close proximity to the treatment area and provide highly conformal dose distributions. This study is a Phase IIa non-randomised interventional pilot trial that will investigate the feasibility of successfully treating patients with 3D-printed custom applicators.

NCT ID: NCT06306170 Recruiting - Gynecologic Cancer Clinical Trials

Advanced Radiotherapy (ART) in Gynecological Cancer Patients (GYN-ART)

GYN-ART
Start date: February 15, 2024
Phase:
Study type: Observational

This is an observational mono-institutional study. Patients with gynecologic tumors treated with advanced radiotherapy- Image Guided Radiotherapy (IGRT), Intensity Modulated Radiotherapy (IMRT), Stereotactic Body Radiotherapy (SBRT)- will be included and toxicity and outcomes analyzed.

NCT ID: NCT06305494 Recruiting - Gynecologic Cancer Clinical Trials

Genitourinary Syndrome of Menopause in Thai Gynecologic Cancer Survivors

Start date: March 14, 2024
Phase:
Study type: Observational

Women often face common cancers like ovarian, uterine, and cervical cancers. Improvements in cancer detection and treatment mean more women survive. However, survivors can encounter challenges like ongoing pain, treatment complications, and fertility issues. Treating these cancers often involves surgeries that might include removing ovaries or using pelvic radiation. This can trigger menopause in younger women, causing problems like vaginal dryness, itching, and urinary issues. Women who've gone through menopause often deal with these symptoms, affecting their daily lives, confidence, and intimate relationships. Though treatments are available, lack of awareness, embarrassment, and not discussing these issues with doctors can make managing them difficult. The main treatment for these symptoms is using vaginal estrogen, but it might not be suitable for some cancer survivors. Non-hormonal options like lubricants and moisturizers are alternatives. This study in Thailand aiming to explore how common these issues are among gynecological cancer survivors, their feelings about it, and how it affects their quality of life.

NCT ID: NCT06278636 Recruiting - Gynecologic Cancer Clinical Trials

Laparoscopic Ultrasound Examination: Analysis of Feasibility

LUXA
Start date: July 18, 2023
Phase:
Study type: Observational

This is a prospective cohort study to assess the feasibility of the laparoscopic ultrasound examination, directly by surgeons, during minimally invasive gynaecological surgery. The secondary aims are to examine the learning curve for laparoscopic ultrasound examination and the performance score in obtaining high quality ultrasound images of anatomical parameters by a team of 5 gynecological laparoscopic fellows. The patients' medical history and symptoms will also be recorded to define whether these clinical data can influence the failure rate. With advanced technology, the conventional workflow can be simplified by using laparoscopic ultrasound probes directly by surgeons, to utilize the hospital resources efficiently and to reduce operating times. In this regard, we would like to demonstrate that the application of laparoscopic examination is feasible and easy to learn by surgeons. This innovative technique could open up multiple diagnostic and therapeutic opportunities for the patient, providing potential clinical information useful to the surgeon.

NCT ID: NCT06278610 Recruiting - Gynecologic Cancer Clinical Trials

Pelvic Exenteration and Laterally Extended Pelvic Resection

Pre-PEX
Start date: November 19, 2020
Phase:
Study type: Observational

Growing evidence in literature is supporting the role of ultrasound scan (US) as accurate tool in diagnosis and staging of gynecologic cancers. In particular, different studies demonstrated the accuracy of US in assessing endometrial, cervical, and ovarian cancer in the primary setting. However, the number of studies investigating the role of US in the recurrent setting is limited. Moreover, there is no evidence in literature exploring the role of US in laterally-extended pelvic recurrences from gynecologic cancer, where the Magnetic Resonance Imaging (MRI) scan is still considered the most accurate tool.

NCT ID: NCT06253182 Recruiting - Breast Cancer Clinical Trials

Psychosexual Educational Partners Program (PEPP)

PEPP
Start date: April 2, 2024
Phase: N/A
Study type: Interventional

The purpose of this study is to compare two Psychosexual Educational programs for women who have completed treatment for breast or gynecological cancer and their partners in preparation for a well-powered phase III study. The investigators plan to enroll 30 dyads in a 2-arm pilot randomized controlled trial (RCT). The primary aim will be to assess the preliminary efficacy of the Psychosexual Educational Partners Program (PEPP) on sexual communication.

NCT ID: NCT06216002 Recruiting - Frailty Clinical Trials

Incidence of Residual Neuromuscular Blockade in Fraility in OncoGynae Surgery

FIGO
Start date: January 2, 2024
Phase: N/A
Study type: Interventional

Frailty among patients undergoing surgery is strongly associated with an elevated risk of adverse perioperative outcomes, heightened incidence of postoperative complications, increased mortality rates, and prolonged hospital length of stay. Our focus centers on investigating the frailty index in the context of complications experienced by patients undergoing oncologic gynecology surgery. The principal objective of this research is to elucidate the extent to which residual neuromuscular blocking agents are linked to frailty.

NCT ID: NCT06215950 Recruiting - Ovarian Cancer Clinical Trials

A Clinical Research About CD70-targeted CAR-T in the Treatment of CD70-positive Advanced/Metastatic Gynecologic Cancer

Start date: January 10, 2024
Phase: Phase 1
Study type: Interventional

This is a single-center, double-arm, open-label study. this study plans to evaluate the safety and efficacy of CD70-targeting CAR-T cells in the treatment of CD70-positive advanced/metastatic Gynecologic Cancer, and obtain recommended doses and infusion patterns.

NCT ID: NCT06139458 Recruiting - Gynecologic Cancer Clinical Trials

Cryocompression to Reduce Chemotherapy-induced Peripheral Neuropathy in Gynecologic Cancer - COHORT 2

Start date: January 18, 2024
Phase: N/A
Study type: Interventional

The investigators aim to determine the effect of cryotherapy wraps plus compression therapy (henceforth referred to as cryocompression) versus cryotherapy wraps alone on the incidence and degree of chemotherapy-induced peripheral neuropathy in patients with gynecologic cancer using a noninferiority design. The investigators also aim to determine the effect of cryocompression versus cryotherapy on patient tolerability and patient and staff satisfaction.

NCT ID: NCT06103526 Recruiting - Gynecologic Cancer Clinical Trials

Immunonutrition in ERAS Protocols in Gynecologic Oncology

NUTRIGO
Start date: October 18, 2023
Phase: N/A
Study type: Interventional

A patient with oncological pathology of any type because of impaired digestion and nutrient absorption, decreased intake, and increased nutrition requirements has an increased risk of malnutrition and moderate to severe weight loss.In the present study the investigators will evaluate the impact of perioperative immunonutrition supplementation on the postoperative outcomes.