Gut Health Clinical Trial
Official title:
Effects of Butyrate on Colonic Health of Patients With Diarrhoea Predominant
Short chain fatty acids (mainly butyrate, acetate, and propionate) are produced in the large
intestine by bacterial fermentation of undigested carbohydrates, such as dietary fibres.
Butyrate is an important energy source of the intestinal epithelium and has a pivotal role
in the regulation of epithelial cell proliferation and differentiation, immune function and
mucosal protection.
Non-digestible carbohydrates (prebiotics) increase the concentrations of colonic butyrate,
which has been proposed to be responsible for its beneficial effects. Furthermore, butyrate
enemas have been proven to be effective in the treatment of active ulcerative colitis.
In the present study, the direct effects of butyrate on inflammation and parameters of
colonic defence and mucosal integrity of the distal colon will be studied in 40 patients
with diarrhoea predominant IBS (D-IBS) and 40 patients with ulcerative colitis in remission
(UCrem) using rectal enemas. These patients groups were chosen because they have a low-grade
inflammation in the large intestine, and can therefore be used as a model to study the
mechanistic effects of butyrate. The design used to study the effects of butyrate in both
patient groups will be a double blind randomized placebo-controlled parallel design.
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