Clinical Trials Logo

Gulf War Illness clinical trials

View clinical trials related to Gulf War Illness.

Filter by:

NCT ID: NCT04255498 Recruiting - Gulf War Illness Clinical Trials

Understanding GWI: Integrative Modeling

Start date: October 30, 2017
Phase: Phase 1
Study type: Interventional

The investigator proposes to perform a Phase I study assessing safety, efficacy, and biomarker response to the therapeutic interventions of Etanercept followed by mifepristone for veterans with Gulf War Illness. The investigator will conduct and repeat the exercise challenge before treatment and on therapy to assess the impact of the interventions on homeostatic regulation and the dynamic model identified in prior studies.

NCT ID: NCT04254627 Recruiting - Gulf War Illness Clinical Trials

TNF and Glucocorticoid Antagonist for GWI Associated Multi-symptom Disease Homeostasis Reset

E/M
Start date: September 24, 2021
Phase: Phase 1
Study type: Interventional

Gulf War Illness is a condition that affects multiple major organ systems, resulting in a diverse array of symptoms that include debilitating fatigue, memory and cognition difficulties, headaches, sleep disturbances, gastrointestinal problems, skin rashes, and musculoskeletal/joint pain. This phase I single-site, open-label two-arm study will assess the safety and mechanistic efficacy of a sequential etanercept-mifepristone intervention for Gulf War Illness. The results of this phase I study will be compared to those from an existing short-duration study to identify the optimal duration and dosage for use in a future phase II study.

NCT ID: NCT04182659 Recruiting - Headache Clinical Trials

Long Term Efficacy of Neuronavigation Guided rTMS in Alleviating Gulf War Illness Related Headaches and Pain Symptoms

Start date: October 1, 2019
Phase: N/A
Study type: Interventional

This study aims to look at the long term efficacy of using repetitive transcranial magnetic stimulation (rTMS) in relieving Gulf War Illness related headaches and pain.

NCT ID: NCT04058275 Recruiting - Gulf War Illness Clinical Trials

"Immunomodulation in GWI (Phlebotomy)"

Start date: September 1, 2018
Phase:
Study type: Observational

Gulf War Illness and deployed veterans of the 1990-1991 Persian Gulf War are invited to have a brief history and physical examination to determine their health status, complete questionnaires, then donate about 83 ml of blood. There is no follow-up

NCT ID: NCT04046536 Recruiting - Depression Clinical Trials

rTMS in Alleviating Pain and Co-Morbid Symptoms in Gulf War Veterans Illness (GWVI)

Start date: October 1, 2019
Phase: N/A
Study type: Interventional

This study aims to look at the effectiveness of using repetitive transcranial magnetic stimulation (rTMS) in relieving pain and other co-morbid symptoms of Gulf War Illness.

NCT ID: NCT03665740 Recruiting - Gulf War Illness Clinical Trials

Multimodal Investigation of the Neuroprotective Effects of Resveratrol (MINER)

MINER
Start date: August 1, 2018
Phase: Phase 2
Study type: Interventional

Since their return from military service in the 1990-1991 Gulf War, many Veterans have been affected by debilitating symptoms that are not easily explained. A leading hypothesis states that the combination of exposure to toxic chemicals and environmental stressors are responsible for a cluster of debilitating symptoms known as Gulf War Illness (GWI). Research has found that over-the-counter antioxidant supplements such as resveratrol may reverse the damage that causes these debilitating symptoms. Resveratrol is a nutrient found abundantly in the skin of red grapes that is known to have robust antioxidant and anti-inflammatory properties. The investigators predict that resveratrol treatment will improve memory issues, difficulties with thinking and mood problems in Veterans with GWI and that resveratrol will do so with minimal risk.

NCT ID: NCT03078530 Recruiting - Gulf War Illness Clinical Trials

Probiotic (Visbiome) for Gulf War Illness

Start date: September 13, 2013
Phase: Phase 2/Phase 3
Study type: Interventional

The overall objective is to determine whether Visbiome will improve 1. intestinal symptoms of Irritable Bowel Syndrome (IBS) and 2. non-intestinal symptoms (fatigue, joint pain, insomnia, general stiffness and headache) associated with IBS. All of these symptoms are part of the Gulf War (GW) illness.

NCT ID: NCT02983734 Recruiting - Gulf War Illness Clinical Trials

D-cycloserine: A Novel Treatment for Gulf War Illness (GWDCS)

GWDCS
Start date: October 2015
Phase: Phase 2
Study type: Interventional

The purpose of this study is to investigate the efficacy of d-cycloserine (DCS) treatment for Gulf War Illness (GWI). Gulf War veterans with Gulf War Illness experience numerous chronic health symptoms, including cognition and fatigue, which reduces their quality of life. Gulf War veterans are in urgent need of novel treatment plans to tackle elusive symptomatology of Gulf War Illness. By using the literature of previous studies, the investigators have chosen to investigate d-cycloserine as a possible candidate for treating GWI, specifically cognitive symptoms. DCS has been shown to reduce neuroinflammation, regulate glutamate levels, and improve synaptic functioning in key areas of the brain.

NCT ID: NCT02357030 Recruiting - Gulf War Illness Clinical Trials

Methylphenidate Plus GWI-Nutrient Formula as a Treatment for Patients With Gulf War Illness

Start date: January 2015
Phase: Phase 2
Study type: Interventional

The Gulf War Synergy Trial will evaluate the safety and efficacy of a currently available medication, methylphenidate (Ritalin®), combined with a GWI Nutrient Formula (K-PAX Synergy) to treat Gulf War Illness (GWI).