Metabolic Diseases Clinical Trial
Official title:
Lipolytic Effects of GH in Human Subjects in Vivo: Molecular Mechanisms and Temporal Patterns
Growth hormone (GH) induces fat metabolism. The mechanisms underlying the fat metabolizing
effects of GH remain elusive. However, it is known that insulin suppresses fat metabolism,
and GH inhibits the expression of certain insulin-dependent signaling proteins. We therefore
hypothesize that the fat metabolizing effects of GH depend on abrogation of insulin-dependent
signaling pathways.
In order to investigate the fat metabolizing effects of GH, we'll analyze consecutive adipose
tissue biopsies taken after GH exposure and GH blocking, respectively.
Knowledge of the effects of growth hormone and fat metabolism can in shot-sight as well as in
long-sight have great importance for the understanding of growth disorders from overweight
and type 2 diabetes to malnutrition and eating disorders.
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