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Growth Hormone Deficiency clinical trials

View clinical trials related to Growth Hormone Deficiency.

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NCT ID: NCT01342146 Completed - Clinical trials for Growth Hormone Deficiency

Efficiency and Safety Study of Pegylated Somatropin to Treat Growth Hormone Deficiency Children

PD
Start date: May 2006
Phase: Phase 2
Study type: Interventional

The purpose of the multicenter, randomized, open-label, controlled phase II study is to determine whether pegylated recombinant human growth hormone is effective in the treatment of children with growth hormone deficiency.

NCT ID: NCT01298180 Completed - Clinical trials for Growth Hormone Deficiency

Is There a Sensibility Increased in the Growth Hormone at Child With Prader-Willi Syndrome?

Start date: January 2009
Phase: Phase 4
Study type: Interventional

The purpose of this study is to estimate the sensibility at the growth hormone in vivo at the children presenting a Prader-Willi syndrome (SPW) in comparison with children presenting a deficit in growth hormone (GHD).

NCT ID: NCT01157793 Completed - Clinical trials for Growth Hormone Deficiency

A Multicentre, Randomised, Open-label, Controlled Study to Evaluate the Effects of Saizen® on Cardiac Function in Growth Hormone Deficient(GHD) Subjects During the Transition Phase From Childhood to Adulthood

Start date: September 2003
Phase: Phase 4
Study type: Interventional

This was a 48-week, open-label, prospective, multicentric, randomised, comparative with parallel control, Phase 4 study to evaluate the effects of Saizen on cardiac function in GHD subjects during the transition phase from childhood to adulthood. The study was designed to evaluate whether recombinant-human growth hormone (r-hGH) treatment also benefits young subjects with GHD. Some trials have already been published on this subject, but they were mainly focused on the bone density.

NCT ID: NCT01120977 Completed - Clinical trials for Growth Hormone Deficiency

Reference Values for Body Composition Parameters and IGF-I in the Adult NordiNet® International Outcome Study

Start date: May 2010
Phase: N/A
Study type: Observational

The treatment of Growth Hormone deficiency (GHD) patients with GH, often induce fluid retention; this effect is dose dependent and temporary. The symptoms are swelling of soft tissue and joint stiffness. The objective of this study is to create bioelectric impedance/arm muscle area (BIA/AMA) reference data, as a measurement of hydration status, of healthy persons of both genders in the age 20-70 years.

NCT ID: NCT01112865 Completed - Clinical trials for Growth Hormone Deficiency

Cross Over Convenience And Preference Study Of New Mark VII Compared To Genotropin Pen In Pediatric And Adult Subjects

CHOOSE
Start date: August 2010
Phase: Phase 3
Study type: Interventional

Convenience and preference for the new Mark VII pen compared to the current Genotropin pen will be assessed using a questionaire. it is expected that the new pen will be preferred or at least no different to the current pen.

NCT ID: NCT01090778 Completed - Clinical trials for Growth Hormone Deficiency

Diurnal Variation of Exogenous Peptides (GH Puls/Jurgita I)

Start date: October 2010
Phase: Phase 2
Study type: Interventional

This is an exploratory trial with four cross-over arms measuring the pharmacokinetic and pharmacodynamic profiles of growth hormone using two different modes of growth hormone administration (subcutaneous infusion into the abdomen or subcutaneous bolus injection in the thigh) in 8 adult male or female patients with growth hormone deficiency during interval exercise or in supine rest. The order of dosing regimen within the groups and between the groups will be randomised. All patients will go through four different treatment sessions:A/B Single subcutaneous bolus injection, supine rest without/with interval exercise, sessions C/D: Continuous subcutaneous infusion, supine rest without/with interval exercise. Hypotheses: 1) There is day-to-day variation of exogenous growth hormone, 2)Concentration of growth hormone decreases due to exercise compared to supine rest, 3)There is a circadian variation in pharmacokinetics of exogenous growth hormone infused subcutaneously

NCT ID: NCT01062529 Completed - Diabetes Clinical Trials

Peripheral Metabolic Effects of Somatostatin

Start date: October 2009
Phase: N/A
Study type: Interventional

The aim of this study is to investigate peripheral effects of Somatostatin on glucose metabolism and growth hormone (GH) signalling in healthy men. Eight subjects will be enrolled. The hypothesis is that Somatostatin infusion reverses insulin resistance caused by GH.

NCT ID: NCT01060488 Completed - Clinical trials for Growth Hormone Deficiency

Comparative Validation of the Growth Hormone Releasing Hormone and Arginine Test for the Diagnosis of Adult Growth Hormone Deficiency

Start date: January 2004
Phase: Phase 3
Study type: Interventional

The aim of the study is to determine the specificity and sensitivity of the combined growth hormone releasing hormone (GHRH) + Arginine test in healthy volunteers, subjects with highly probable adult growth hormone deficiency (AGHD) and subjects who were probably free of AGHD.

NCT ID: NCT01034735 Completed - Clinical trials for Growth Hormone Deficiency

r-hGH Liquid Multidose Versus Freeze-dried Multidose Bioequivalence Trial

Start date: July 2008
Phase: Phase 1
Study type: Interventional

The primary objective of the trial was to assess the bioequivalence for two concentrations (5.83 mg/mL and 8 mg/mL) of the new r-hGH liquid multidose formulation using the r hGH freeze-dried multidose formulation (Saizen® 8 mg, 8.8 mg/1.51 mL) as reference. Each volunteer received three r hGH treatments, with each treatment being administered as a single subcutaneous dose of 4 mg r-hGH in a randomized sequence with at least one week of wash-out period between successive treatments.

NCT ID: NCT00990340 Completed - Clinical trials for Growth Hormone Deficiency

Comparison of a Needle-free Injection Method With a Needle-syringe Injection Method

T-jet®
Start date: September 2009
Phase: Phase 4
Study type: Interventional

The purpose of this study is to obtain psychological response and user preference information on the use of the T jet® device versus the traditional subcutaneous injection administration of Tev Tropin®. This study will compare subject-reported injection anxiety immediately before the administration of each dose of Tev-Tropin® between a needle-syringe injection method and a needle-free injection method (T-jet®)