Growth Hormone in a Patient With a Dominant-Negative GHR Mutation

Status Active, not recruiting

Clinical Trial Summary

This is a prospective interventional study designed for a single patient with a dominant-negative mutation in the growth hormone receptor gene (GHR) which results in increased levels of growth hormone binding protein (GHBP). The patient will receive escalating doses of growth hormone titrated to achieve an insulin like growth factor-1 level above the mean and then growth response to therapy will be monitored.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Growth Disorders

Clinical Trial Details

NCT number	NCT05382637
Study type	Interventional
Source	Children's National Research Institute
Contact
Status	Active, not recruiting
Phase	Phase 2
Start date	August 26, 2022
Completion date	September 1, 2028

View Details

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