Growth Disorders Clinical Trial
Official title:
Pattern of Growth and Characteristics of Down Syndrome Pediatrics Patients Attending Assuit University Children Hospital
Down syndrome or Down's syndrome (DS), also known as trisomy 21, is a genetic disorder caused by the presence of all or part of a third copy of chromosome 21. It is usually associated with physical growth delays, mild to moderate intellectual disability, and characteristic facial features. The parents of the affected individual are usually genetically normal. The probability increases from less than 0.1% in 20-year-old mothers to 3% in those of age 45 .
People with DS may have some or all of these physical characteristics: a small chin, slanted eyes, poor muscle tone, a flat nasal bridge, a single crease of the palm, and a protruding tongue due to a small mouth and relatively large tongue. Other features include: a flat and wide face, a short neck, excessive joint flexibility, extra space between big toe and second toe, abnormal patterns on the fingertips and short fingers. Short stature is a characteristic feature of DS. Growth retardation of DS individuals starts prenatally. After birth, the growth velocity is most reduced between 6 months to 3 years . Growth charts specific for children with DS are important tools for routine medical follow-up, as well as early identification of pathological causes of growth retardation, and monitoring of growth promoting treatments. Growth charts for DS are available from different countries, for example, Italy, USA, Denmark, Sweden, Portugal, France, UK and Ireland and Saudi Arabia . ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT01376921 -
To Assess the Level of Adherence of Subjects Receiving SAIZEN® Via Easypod™ in Spain
|
N/A | |
| Completed |
NCT01400997 -
Level of Adherence of Subjects Receiving SAIZEN® Via Easypod™ in Czech Republic
|
N/A | |
| Completed |
NCT05244785 -
Health and Nutrition Survey on Shenzhen Children
|
||
| Completed |
NCT00097539 -
A Postmarketing Surveillance Program for Nutropin, Nutropin AQ, and Protropin
|
Phase 4 | |
| Not yet recruiting |
NCT04576845 -
The Effect of Early Childhood Cow's Milk Allergy Elimination Diet on Eating Behaviors, Nutrition, and Growth Status
|
||
| Completed |
NCT01263457 -
To Assess the Level of Adherence of Subjects Receiving SAIZEN® Via Easypod™ in the UK
|
||
| Terminated |
NCT00330668 -
Treatment of Children and Adolescents With Growth Failure Associated With Primary IGF-1 Deficiency
|
Phase 3 | |
| Completed |
NCT00378859 -
The Effect of Milk and Meat on IGFs in Prepubertal Boys
|
N/A | |
| Not yet recruiting |
NCT05577130 -
Growth Pattern and Characteristics of Cardiac Pediatric Patients
|
||
| Recruiting |
NCT05033119 -
PROSA: Prolactin, Sex Hormones, Growth and Metabolic Biomarkers in Children and Adolescents on Antipsychotics
|
||
| Completed |
NCT01402999 -
To Assess the Level of Adherence of Subjects Receiving SAIZEN® Via Easypod™ in Hungary
|
N/A | |
| Completed |
NCT01267526 -
A Canadian, Multi-centre, Observational Registry to Study Adherence and Long Term Outcomes of Therapy in Pediatric Subjects Using SAIZEN® Via Easypod™ Auto-injector for Growth Hormone Treatment
|
N/A | |
| Completed |
NCT00139451 -
Nutrients and Hormones: Effects in Boys With Disordered Growth
|
Phase 2 | |
| Terminated |
NCT03274973 -
Study to Assess Long-term Effectiveness of Zomacton® and Treatment Adherence in Patients With Growth Hormone Deficiency or Ullrich-Turner Syndrome
|
||
| Completed |
NCT02015286 -
To Assess the Level of Adherence of Subjects Receiving SAIZEN® Via Easypod™ in Middle East
|
N/A | |
| Completed |
NCT01582334 -
To Assess the Level of Adherence of Subjects Receiving SAIZEN® Via Easypod™ in Argentina
|
N/A | |
| Completed |
NCT01439061 -
To Assess the Level of Adherence of Subjects Receiving SAIZEN® Via Easypod™ in Italy
|
N/A | |
| Completed |
NCT00125164 -
Prepubertal Children With Growth Failure Associated With Primary Insulin-Like Growth Factor-1 (IGF-1) Deficiency
|
Phase 3 | |
| Completed |
NCT00174408 -
Treatment Of Children With Short Stature At An Age Of 3-7 Years Who Were Born Small For Gestational Age
|
Phase 3 | |
| Recruiting |
NCT05829252 -
Testing the Feasibility of a Novel Growth Monitoring Smartphone App
|