Differential Diagnosis of STA-PSV in Thyrotoxicosis

Graves Disease Clinical Trial

Official title:

Differential Diagnosis Value of Peak Systolic Velocity of Thyroid Superior Artery Using Color Flow Doppler Sonography in Transient Thyrotoxicosis Caused by Thyroiditis and Graves Disease

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01227499
• Other study ID #: huashan001
• Status: Completed
• Phase: N/A
• First received: October 22, 2010
• Last updated: May 2, 2014
• Start date: June 2010
• Est. completion date: November 2011

Study information

• Verified date: May 2014
• Source: Huashan Hospital
• Contact: n/a
• Is FDA regulated: No
• Health authority: China: Ministry of Health
• Study type: Observational

Clinical Trial Summary

Aim: Graves's disease and thyroiditis can both characterized with thyrotoxicosis, but their clinical outcome and therapy is quiet different. Measurement of iodine uptake is the gold standard to differential diagnosis the thyroiditis or Graves's disease. But the iodine uptake is limited for its availability in china and easily influenced by medicine or food contained iodine.The blood pattern of thyroid CFDS is useful for differentiate the cause of thyrotoxicosis.Most previous studies using the descriptive pattern of thyroid CFDS is easily varied by operator subjective judgement. This study is focus on the role of peak systolic velocity of thyroid superior artery in differential diagnosis of thyrotoxicosis. Methods: Patients with thyrotoxicosis symptoms without recent medicine history were enrolled in two clinical center. Its thyroid function, iodine uptake , CFDS of thyroid and peak systolic velocity of thyroid superior artery is detected. Thyrotoxicosis is defined as TSH level below the low value of normal range. Graves disease is defined as the typical symptoms of graves disease such as graves ophthalmopathy or increased iodine uptake. Thyroiditis is defined as lack of typical symptoms of graves disease or decreased iodine uptake.We use receiver operator curve(ROC) to evaluate its diagnosis value

Recruitment information / eligibility

• Status: Completed
• Enrollment: 169
• Est. completion date: November 2011
• Est. primary completion date: November 2011
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 15 Years to 85 Years

Eligibility

Inclusion Criteria:

• newly diagnosed without taking any antithyroid drug or beta receptor blocker with TSH level below the lower limits of reference range

• is willing to be enrolled

Exclusion Criteria:

• unwilling

• taking antithyroid drug or beta receptor blocker

• taking foods or medicine rich in iodine in 8 weeks

• women with pregnant or lactation

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

• Graves Disease
• Peak Systolic Velocity of Superior Thyroid Artery
• Thyroiditis
• Thyrotoxicosis

Locations

Country	Name	City	State
China	Xiaolong Zhao	Shanghai	Shanghai

Sponsors (3)

Lead Sponsor	Collaborator
xiaolong zhao	Fudan University, Zhongda Hospital

Country where clinical trial is conducted

China, 

References & Publications (1)

Zhao X, Chen L, Li L, Wang Y, Wang Y, Zhou L, Zeng F, Li Y, Hu R, Liu H. Peak systolic velocity of superior thyroid artery for the differential diagnosis of thyrotoxicosis. PLoS One. 2012;7(11):e50051. doi: 10.1371/journal.pone.0050051. Epub 2012 Nov 16. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Other	thyroid funciton		December 1, 2013	No
Primary	mean STA-PSV	the mean STA-PSV	2014-04-07	No
Primary	uptake of iodine		December 1, 2013	Yes
Secondary	PSV		December 1, 2013	Yes