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Clinical Trial Summary

Graves' disease (GD) is one of organ specific autoimmune diseases, the pathogenesis is not elucidated.Natural Killer (Natural Killer, NK) cells is a kind of important immune regulator, several abnormalities of NK cell function and number in GD patients have been described in the investigators' previous study. It is remain unclear whether the NK cell disfunction is a consequence of GD.Based on the investigators' previous study, the investigators plan to monitor NK cell function in participants in the whole course of disease, analyze the association with relevant factors, such as thyroid function, immune state or treatment,to find out influences of thyroid hormones and thyroid receptor antibody affecting the function of NK cell. The investigators will reveal whether the disfunction of NK cell secondary to GD abnormal thyroid function and/or immune disorders, and realize the mechanics.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT04135573
Study type Observational [Patient Registry]
Source Shandong Provincial Hospital
Contact
Status Active, not recruiting
Phase
Start date October 15, 2018
Completion date June 30, 2022

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