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Clinical Trial Summary

In this study the investigators are proposing to treat patients with steroid-refractory Graft-versus-host Disease (GVHD) stabilization using IL-2 and azacitidine


Clinical Trial Description

High-dose cyclophosphamide and sirolimus have been successfully used for the prevention of Graft-versus-host Disease (GVHD) and have shown to enhance the Tregs subpopulation. The addition of low dose IL-2 and a demethylating agent such as azacitidine will also be studied in an attempt to promote and stabilize the FoxP3 expression of Tregs. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT01453140
Study type Interventional
Source Hackensack Meridian Health
Contact
Status Terminated
Phase Phase 1/Phase 2
Start date August 2011
Completion date July 2012

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