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Dendritic Cells in Patients Following Allogeneic Hematopoietic Stem Cell Transplantation — DCalloTX  

Graft Versus Host Disease Clinical Trial

Official title:
Analysis of Dendritic Cells in Patients Following Allogeneic Hematopoietic Stem Cell Transplantation

Clinical Trial Summary

We plan to investigate prospectively and simultaneously skin and blood DC subtypes, their donor/recipient origin and the correlation of DC reconstitution kinetics with treatment, clinical outcome and incidence of aGvHD in patients undergoing allogeneic hematopoietic stem cell transplantation.

Clinical Trial Description

Blood and skin DC reconstitution shall be investigated in patients affected by hematological diseases and receiving HLA-matched, mobilized peripheral blood stem cells from related or unrelated donors. We plan to simultaneously collect and process double biopsies, i.e. from graft versus host disease affected and non-lesional skin of patients at onset of acute graft versus host disease following allogeneic hematopoietic stem cell transplantation. Emigration assay, Chimerism analysis and immunohistochemistry will be performed. ;

Study Design

Observational Model: Defined Population, Time Perspective: Cross-Sectional

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00450268
Study type Observational
Source Technische Universität Dresden
Contact Susanne Gretzinger, MD
Phone +49 351 458
Email susanne.gretzinger@uniklinik-dresden.de
Status Recruiting
Phase N/A
Start date January 2005
Completion date January 2010
View Details
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