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Clinical Trial Details — Status: Terminated

Administrative data

NCT number NCT00006054
Other study ID # 199/15104
Secondary ID UMN-MT-1995-26UM
Status Terminated
Phase N/A
First received July 5, 2000
Last updated October 14, 2009
Start date March 2000
Est. completion date December 2002

Study information

Verified date October 2003
Source Office of Rare Diseases (ORD)
Contact n/a
Is FDA regulated No
Health authority Unspecified
Study type Interventional

Clinical Trial Summary

OBJECTIVES: I. Provide curative immunoreconstituting allogeneic bone marrow transplantation for patients with primary immunodeficiencies.

II. Determine relevant outcomes of this treatment in these patients including quality of survival, extent of morbidity and mortality from complications of the treatment (e.g., graft versus host disease, regimen related toxicities, B- cell lymphoproliferative disease), and completeness of functional immunoreconstitution.


Description:

PROTOCOL OUTLINE: Patients with severe combined immunodeficiency (SCID) using a matched sibling donor receive allogeneic bone marrow or umbilical cord blood transplantation on day 0. Patients receive graft versus host disease (GVHD) prophylaxis with methotrexate IV on days 1, 3, 6, and 11 and cyclosporine IV on days -3 to 50.

Patients with SCID using donors other than histocompatible siblings, Wiskott Aldrich syndrome using a histocompatible sibling donor, Wiskott Aldrich syndrome and under 5 years of age using donors other than histocompatible siblings, X-linked CD40 ligand deficiency using a histocompatible sibling donor, X-linked CD40 ligand deficiency and under 5 years of age using donors other than histocompatible siblings, other primary immunodeficiencies without manifestations of hemophagocytosis using a histocompatible sibling donor, or other primary immunodeficiencies without manifestations of hemophagocytosis and under 5 years of age using donors other than histocompatible siblings receive busulfan IV over 2 hours every 6 hours on days -9 to -6, cyclophosphamide IV on days -5 to -2, and antithymocyte globulin (ATG) twice daily on days -4 to -1. Allogeneic bone marrow or umbilical cord blood transplantation takes place on day 0. Patients receive graft versus host disease (GVHD) prophylaxis with methotrexate IV on days 1, 3, 6, and 11 and cyclosporine IV on days -3 to 50.

Patients with hemophagocytic lymphohistiocytosis, Chediak Higashi syndrome, X-linked lymphoproliferative syndrome, severe progressive Langerhans cell histiocytosis, or other primary immunodeficiencies with complications of hemophagocytosis receive busulfan IV over 2 hours every 6 hours on days -9 to -6, cyclophosphamide IV over 2 hours on days -5 to -2, etoposide IV over 22 hours on days -5 to -3, and ATG IV twice daily on days -2, -1, 1, and 2. Allogeneic bone marrow or umbilical cord blood transplantation takes place on day 0. Patients receive graft versus host disease (GVHD) prophylaxis with methotrexate IV on days 1, 3, 6, and 11 and cyclosporine IV on days -3 to 50.

Patients with Wiskott Aldrich syndrome or other primary immunodeficiencies without manifestations of hemophagocytosis, who are over 5 years of age and using donors other than histocompatible siblings, receive busulfan IV over 2 hours every 6 hours on days -6 and -5, cyclophosphamide IV over 2 hours on days -4 and -3, total body irradiation on day -2, and ATG IV over 2 hours twice daily on days -2, -1, 2, and 3. Allogeneic bone marrow or umbilical cord blood transplantation takes place on days 0 and 1. Patients receive GVHD prophylaxis with methylprednisolone IV every 12 hours on days 2-21, oral prednisone every 12 hours on days 22-100 and then tapered off over days 101 to 128, and cyclosporine IV over 2 hours every 8-12 hours on days -3 to 100.

All patients are followed as determined by their primary physician.


Recruitment information / eligibility

Status Terminated
Enrollment 0
Est. completion date December 2002
Est. primary completion date December 2002
Accepts healthy volunteers No
Gender Both
Age group N/A to 35 Years
Eligibility - Severe combined immunodeficiency All ages with histocompatible sibling donors or with other donors OR Wiskott Aldrich syndrome All ages with histocompatible sibling donors or with other donors OR X-linked CD40 ligand deficiency All ages with histocompatible sibling donors OR Under 5 years of age with donors other than histocompatible siblings OR Other primary immunodeficiencies without manifestations of hemophagocytosis All ages with histocompatible sibling donors or with other donors OR Hemophagocytic lymphohistiocytosis (HLH) Familial erythrophagocytic lymphohistiocytosis (FEL), familial HLH (FHLH), recurrent virus-associated hemophagocytic syndrome (VAHS) All ages with related or unrelated donors OR Chediak Higashi syndrome All ages with related or unrelated donors OR X-linked lymphoproliferative syndrome All ages with related or unrelated donors OR Other primary immunodeficiencies with complication of hemophagocytosis All ages with related or unrelated donors OR Severe progressive Langerhans cell histiocytosis All ages with related or unrelated donors

Study Design

Primary Purpose: Treatment


Related Conditions & MeSH terms

  • Agammaglobulinemia
  • Chediak-Higashi Syndrome
  • Chronic Granulomatous Disease
  • Common Variable Immunodeficiency
  • Familial Erythrophagocytic Lymphohistiocytosis
  • Genetic Diseases, X-Linked
  • Graft Versus Host Disease
  • Graft vs Host Disease
  • Granuloma
  • Granulomatous Disease, Chronic
  • Hemophagocytic Lymphohistiocytosis
  • Immunologic Deficiency Syndromes
  • Leukocyte Adhesion Deficiency Syndrome
  • Leukocyte-Adhesion Deficiency Syndrome
  • Lymphohistiocytosis, Hemophagocytic
  • Lymphoproliferative Disorders
  • Severe Combined Immunodeficiency
  • Syndrome
  • Virus-Associated Hemophagocytic Syndrome
  • Wiskott-Aldrich Syndrome
  • X-linked Agammaglobulinemia
  • X-linked Hyper IgM Syndrome
  • X-Linked Lymphoproliferative Syndrome

Intervention

Drug:
anti-thymocyte globulin

busulfan

cyclophosphamide

cyclosporine

etoposide

methotrexate

methylprednisolone

prednisone

Procedure:
Allogeneic Bone Marrow Transplantation


Locations

Country Name City State
United States Fairview University Medical Center Minneapolis Minnesota

Sponsors (1)

Lead Sponsor Collaborator
Fairview University Medical Center

Country where clinical trial is conducted

United States, 

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