View clinical trials related to Goiter.
Filter by:The extent of thyroid resection in benign goiter is controversial. Potential advantages of TT over BST may include: one-stage removal of incidental thyroid cancer reported in up to 10% of operatively treated benign thyroid diseases, and lower risk for goiter recurrence. However, these potential advantages should outweigh the risk of morbidity associated with more radical thyroid resection. The aim of this study was to compare outcomes of bilateral subtotal (BST) vs. total thyroidectomy (TT) for benign bilateral thyroid disease.
Primary Objectives - To compare the amount of post-operative wound drainage between the group of patients in which EVICEL™ spray is utilized (Arm A), and the group of patients in which an EVICEL™ placebo is utilized (Arm B). - To compare the length of time to drain removal between Arm A and Arm B. Secondary objectives - To compare the incident or rates of seroma, hematoma, and post-operative edema between the two groups. - To compare the reported pain experienced in each group at selected time points using a standard numerical rating scale (NRS). - To compare the length of hospital stay between the two groups of patients.
The purpose of this study is to evaluate the technical benefits, advantages and limits of the use of the Harmonic Focus curved shears in total thyroidectomy.
The aim of this three-arm randomized study was to evaluate results of different thyroid resection modes among patients with bilateral multinodular non-toxic goiter, with special emphasis put on recurrence rate and morbidity rate, in a 5-year follow-up.
The aim of this study is to compare aesthetic results of two different type of sutures (subcuticular versus synthetic glue) in post-thyroidectomy incisions. It is a randomized clinical trial (single blinded) designed as a superiority study, since in the authors' hypotheses glue can give better results compared with subcuticular suture in this particular district. Secondary objective is to investigate if other factors (like the use of cold/warm blade, the sex, the presence of diabetes, the lenght of incision) can influence aesthetic results.
Protocol Synopsis - Protocol title: Late postoperative course of patients with mini Video Assisted Thyroidectomy (miVAT) versus classic Thyroidectomy (T) - Purpose: Comparison of the late postoperative course and complications of the patients using the two techniques - Design: Prospective, single-center randomized study - Patient Population: Male or female subjects 18 years of age or older with nodular goiter who are scheduled for total thyroidectomy (miVAT or T) - No. of Subjects: 100 patients divided into two groups, estimated up to 1 year to enroll - Duration of Treatment: During the operation - Duration of Follow-up: Follow-up will be performed by evaluation at the 3rd and 6th postoperative month ±5 days - Endpoints: To evaluate the long term safety of each technique
Protocol Synopsis - Protocol title: Immediate postoperative course of patients with mini Video Assisted Thyroidectomy (miVAT) versus classic Thyroidectomy (cTT) - Purpose: Comparison of the immediate postoperative course and complications of the patients using the two techniques - Design: Prospective, single-center randomized study - Patient Population: Male or female subjects 18 years of age or older with nodular goiter who are scheduled for total thyroidectomy (miVAT or T) - No. of Subjects: 100 patients divided into two groups, estimated up to 1 year to enroll - Duration of Treatment: During the operation - Duration of Follow-up: Follow-up will be performed daily while hospitalized, and by phone till the 7th postoperative day - Endpoints: To evaluate the safety and cost-effectiveness of each technique
Protocol Synopsis - Design: Prospective, single-center randomized study Patient Population: Male or female subjects 18 years of age or older who are scheduled for total thyroidectomy - No. of Subjects: 100 patients divided into two groups, estimated up to 6 months to enroll - Duration of Treatment: During the operation - Duration of Follow-up: Follow-up will be performed daily while hospitalized, and by phone till the 7th postoperative day - Endpoints: To evaluate the safety and cost-effectiveness of each technique
Pleuropulmonary Blastoma (PPB) is a rare lung tumor which develops in childhood. The underlying genetic factors which contribute to the development and progression of PPB are not defined. We are working to identify the genetic factors which may contribute to the development of this rare tumor.
Background: Preadministration of recombinant human thyrotropin (rhTSH) increases the amount and homogeneity of thyroid radioiodine uptake, and when used as an adjuvant can augment the efficiency of 131I therapy by allowing multinodular goitre (MNG) volume reduction. Objective: The investigators aimed to assess low-dose rhTSH-aided fixed-activity radioiodine therapy outcome in MNG patients. Design: This was a long-term (36 months) observational study. Methods: The investigators measured 24 h thyroid radioiodine uptake (RAIU) of 1.4 µCi (0.5 MBq) of 131-iodine at baseline and 24 h after intramuscular injection of 0.1 mg rhTSH in 42 patients (aged 42-80 years) who subsequently received 30 mCi 131-iodine 24 h after an identical rhTSH injection. Urinary iodine was measured at baseline and at 3 months after following a low iodine diet. TSH, free thyroxine (FT4), T3 (T3) and thyroglobulin (TG) were measured at baseline, 24 h, 48 h, 72 h, 168 h, one month, 3, 6, 9, 12, 18, 24 and 36 months after therapy. Thyroid volume was assessed by computer tomography at baseline and every 6 months thereafter.