The Effects of L-arabinose in a Meal in Healthy Men

Glucose Metabolism Clinical Trial

Official title:

The Effects of L-arabinose in a Meal on Glucose Metabolism in Healthy Men

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01801540
• Other study ID #: H-2-2010-095
• Status: Completed
• Phase: N/A
• First received: February 27, 2013
• Last updated: February 27, 2013
• Start date: December 2010
• Est. completion date: March 2011

Study information

• Verified date: February 2013
• Source: University of Copenhagen
• Contact: n/a
• Is FDA regulated: No
• Health authority: Denmark: Ethics Committee
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to investigate the effect of a meal containing different doses of L-arabinose, on the intestinal sucrase activity after intake We measure this by measuring the glucose, insulin and c-peptide after meals. Other measurements are made (glucagon and GLP-1) to explain the correlations.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 17
• Est. completion date: March 2011
• Est. primary completion date: March 2011
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 18 Years to 30 Years

Eligibility

Inclusion Criteria:

• Healthy male

• normal weight (BMI 18,5-25 kg/m2)

• 18-30 years of age

Exclusion Criteria:

• Not healthy,including those with diabetes Mellitus, high bloodpressure, dyslipidemia or a infectious diseases (hepatitis or HIV), gastrointestinal disorders

• Central adipositas (defined as waist circumference > 94 cm for european men)

• Daily intake of vitamins and minerals, 3 months before the trail starts and during the trail.

• elevated alcoholcunsumption(> 21 units af alcohol pr. week)

• take medicine

• Elite athlete with intensive training

• given bloddonation within the last 3 months

• smoking

Study Design

Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Prevention

Related Conditions & MeSH terms

• Glucose Metabolism

Intervention

Dietary Supplement:
• L-arabinose - effect on glucose metabolism
L-arabinose is mixed into the dough of the buns and cup cakes

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
University of Copenhagen

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Glucose	Level of glucose over time, The AUC, the peak value and time to peak	-15, 0, 15, 30, 45, 60, 90, 120, 180 min	No
Primary	Insulin	Level of insulin over time, the AUC, the peak value and time to peak	-15, 0, 15, 30, 45, 60, 90, 120, 180 min	No
Primary	C-peptide	Level of c-peptide over time, The AUC, the peak value and time to peak	-15, 0, 15, 30, 45, 60, 90, 120, 180 min	No
Secondary	Glucagon	Level of glucagon over time, The AUC, the peak value and time to peak	-15, 0, 15, 30, 45, 60, 90, 120, 180 min	No
Secondary	GLP-1	Level of GLP-1 over time, The AUC, the peak value and time to peak	-15, 0, 15, 30, 45, 60, 90, 120, 180 min	No