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Clinical Trial Details — Status: Recruiting

Administrative data

NCT number NCT06242015
Other study ID # 24-003
Secondary ID
Status Recruiting
Phase N/A
First received
Last updated
Start date February 6, 2024
Est. completion date July 30, 2025

Study information

Verified date April 2024
Source Old Dominion University
Contact Patrick Wilson, PhD
Phone 757-683-4783
Email pbwilson@odu.edu
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

There is well documented evidence that ingesting dietary carbohydrate in large amounts tends to increase postprandial glucose. In healthy populations, this is not necessarily a problem, but continuous exposure to high levels of glucose-hyperglycemia-is a defining characteristic and risk factor for type 2 diabetes mellitus. Consuming a carbohydrate-rich food as the final food in a meal sequence has been shown to significantly reduce postprandial glucose excursions in both diabetes patients and in healthy controls. The exact mechanisms behind this phenomenon are not well understood, but one proposed course is simply that the vegetable and protein already being digested slows the rate of glucose rise. Despite the findings, little-to-no research has examined how manipulating the order of foods in a meal impacts subsequent exercise responses. In this experimental crossover study, each participant will undergo two acute feeding conditions (carbohydrate-rich foods first vs. last in a meal), which will be followed by exercise 60 minutes later. We will observe the effects of meal order on postprandial glucose, substrate/fuel utilization, and subjective perceptions at rest and during 30 minutes of exercise.


Recruitment information / eligibility

Status Recruiting
Enrollment 30
Est. completion date July 30, 2025
Est. primary completion date July 30, 2025
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 18 Years to 60 Years
Eligibility Inclusion Criteria: - Currently physically active (scheduled exercise at least three days per week for 30 minutes each time over the last three months) - Ability to perform moderate-to-high intensity running for at least 30 minutes Exclusion Criteria: - Any allergy or other condition that would prohibit the consumption of poultry, rice, or broccoli - Any injury or disease (cardiovascular disease, diabetes, pulmonary disease except controlled asthma) precluding physical exercise - Currently pregnant - Implanted electrical devices such as a pacemaker.

Study Design


Related Conditions & MeSH terms


Intervention

Other:
Carbohydrate-first meal
Rice (150 grams) eaten first, followed by broccoli (150 grams) and chicken (100 grams)
Carbohydrate-last meal
Broccoli (150 grams) and chicken (100 grams) eaten first, followed by rice (150 grams)

Locations

Country Name City State
United States ODU Human Performance Laboratory Norfolk Virginia

Sponsors (1)

Lead Sponsor Collaborator
Old Dominion University

Country where clinical trial is conducted

United States, 

Outcome

Type Measure Description Time frame Safety issue
Primary Postprandial glucose Blood glucose will be measured with fingerstick samples and a portable glucometer 2 hours (premeal and 30, 60, 90, and 120 minutes after eating)
Secondary Carbohydrate use Carbohydrate utilization will be estimated from respiratory gas exchange 100 minutes (premeal and continuously for 90 minutes after eating)
Secondary Fat use fat utilization will be estimated from respiratory gas exchange 100 minutes (premeal and continuously for 90 minutes after eating)
Secondary Hunger-satiety perceptions Hunger, appetite, satiety, and fullness on a 0-10 Likert scale 2 hours (Premeal and at 15, 30, 45, 60, 68, 78, 88, 120 minutes after eating)
Secondary Rating of perceived exertion Rating of effort during 30-minute exercise bout 30 minutes (at 8, 18, 28 minutes of exercise)
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