Ordered Eating and Acute Exercise

Glucose Metabolism Disorders Clinical Trial

Official title:

The Effect of Ordered Eating on Postprandial Glucose and Substrate Utilization During an Acute Exercise Bout

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT06242015
• Other study ID #: 24-003
• Status: Recruiting
• Phase: N/A
• Start date: February 6, 2024
• Est. completion date: July 30, 2025

Study information

• Verified date: April 2024
• Source: Old Dominion University
• Contact: Patrick Wilson, PhD
• Phone: 757-683-4783
• Email: pbwilson[@]odu.edu
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

There is well documented evidence that ingesting dietary carbohydrate in large amounts tends to increase postprandial glucose. In healthy populations, this is not necessarily a problem, but continuous exposure to high levels of glucose-hyperglycemia-is a defining characteristic and risk factor for type 2 diabetes mellitus. Consuming a carbohydrate-rich food as the final food in a meal sequence has been shown to significantly reduce postprandial glucose excursions in both diabetes patients and in healthy controls. The exact mechanisms behind this phenomenon are not well understood, but one proposed course is simply that the vegetable and protein already being digested slows the rate of glucose rise.

Despite the findings, little-to-no research has examined how manipulating the order of foods in a meal impacts subsequent exercise responses. In this experimental crossover study, each participant will undergo two acute feeding conditions (carbohydrate-rich foods first vs. last in a meal), which will be followed by exercise 60 minutes later. We will observe the effects of meal order on postprandial glucose, substrate/fuel utilization, and subjective perceptions at rest and during 30 minutes of exercise.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 30
• Est. completion date: July 30, 2025
• Est. primary completion date: July 30, 2025
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 60 Years

Eligibility

Inclusion Criteria:

• Currently physically active (scheduled exercise at least three days per week for 30 minutes each time over the last three months)

• Ability to perform moderate-to-high intensity running for at least 30 minutes

Exclusion Criteria:

• Any allergy or other condition that would prohibit the consumption of poultry, rice, or broccoli

• Any injury or disease (cardiovascular disease, diabetes, pulmonary disease except controlled asthma) precluding physical exercise

• Currently pregnant

• Implanted electrical devices such as a pacemaker.

Related Conditions & MeSH terms

• Glucose Metabolism Disorders
• Hunger
• Metabolic Diseases

Intervention

Other:
• Carbohydrate-first meal
Rice (150 grams) eaten first, followed by broccoli (150 grams) and chicken (100 grams)
• Carbohydrate-last meal
Broccoli (150 grams) and chicken (100 grams) eaten first, followed by rice (150 grams)

Locations

Country	Name	City	State
United States	ODU Human Performance Laboratory	Norfolk	Virginia

Sponsors (1)

Lead Sponsor	Collaborator
Old Dominion University

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Postprandial glucose	Blood glucose will be measured with fingerstick samples and a portable glucometer	2 hours (premeal and 30, 60, 90, and 120 minutes after eating)
Secondary	Carbohydrate use	Carbohydrate utilization will be estimated from respiratory gas exchange	100 minutes (premeal and continuously for 90 minutes after eating)
Secondary	Fat use	fat utilization will be estimated from respiratory gas exchange	100 minutes (premeal and continuously for 90 minutes after eating)
Secondary	Hunger-satiety perceptions	Hunger, appetite, satiety, and fullness on a 0-10 Likert scale	2 hours (Premeal and at 15, 30, 45, 60, 68, 78, 88, 120 minutes after eating)
Secondary	Rating of perceived exertion	Rating of effort during 30-minute exercise bout	30 minutes (at 8, 18, 28 minutes of exercise)