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NCT03232008 Clinical Trial

Canderel:Effects on Blood Glucose Concentration and Appetite Scores

Glucose Metabolism Disorders Clinical Trial

Official title:
The Effects of Canderel (Aspartame and Acesulfame-k Blend) on Blood Glucose Concentration and Appetite Scores in Humans: a Randomised Controlled Trial

Clinical Trial Details — Status: Active, not recruiting

Administrative data
NCT number NCT03232008
Other study ID # KCLMScNutr2017
Secondary ID
Status Active, not recruiting
Phase N/A
First received
Last updated
Start date September 1, 2015
Est. completion date March 28, 2021

Study information
Verified date September 2020
Source King's College London
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

This study investigates the effects of Canderel, an aspartame and acesulfame-k blend artificial sweetener powder, on post-postprandial blood glucose levels and appetite scores.

Description:

The study is separated into two parts: A) investigating the effects of artificial sweeteners in combination with complex carbohydrates; and B) investigating the effects of artificial sweeteners in combination with simple sugars.

A) Participants will be randomly given either the placebo drink (3g of maltodextrin dissolved in 250ml of water) or the Canderel drink (3g of Canderel dissolved in 250ml of water) alongside an isocaloric high carbohydrate breakfast. Blood glucose measurements will be obtained through finger pricking and appetite will be measured using self-reported visual analog scores rating hunger, desire to eat, fullness and alertness for up to 3 hours after breakfast.

B)Participants will be randomly given either the placebo drink (3g of Lyle's Golden syrup and 3g of maltodextrin dissolved in 250ml of water) or the Canderel+sugars drink (3g of Canderel and 3g of Lyle's Golden syrup dissolved in 250ml of water) . Blood glucose measurements will be obtained through finger pricking and appetite will be measured using self-reported visual analog scores rating hunger, desire to eat, fullness and alertness for up to 3 hours after drink

Recruitment information / eligibility
Status Active, not recruiting
Enrollment 110
Est. completion date March 28, 2021
Est. primary completion date February 28, 2019
Accepts healthy volunteers No
Gender All
Age group 18 Years to 64 Years
Eligibility Inclusion Criteria:

- Healthy male and female adults (18-64)

Exclusion Criteria:

-

Study Design

Related Conditions & MeSH terms

Intervention

Dietary Supplement:
• Canderel drink
1.4% aspartame and 0.95% acesulfame-k and 95% maltodextrin; 3g dissolved in 250ml of water
• Canderel+Lyle's Golden Syrup drink
Canderel: 1.4% aspartame and 0.95% acesulfame-k and 95% maltodextrin; 3g dissolved in 250ml of water Lyle's Golden Syrup: 35 g (27g of glucose and fructose)

Locations
Country Name City State
United Kingdom King's College London London

Sponsors (1)
Lead Sponsor Collaborator
King's College London

Country where clinical trial is conducted

United Kingdom, 

Outcome
Type Measure Description Time frame Safety issue
Primary Change in Blood glucose Capillary blood obtained from fingerprick and measured using glucose monitor 0-180min (Measured from baseline to 90min every 15min; 90-180min every 30min)
Primary Change in Appetite Feelings of hunger, desire to eat, fullness and alertness measured using Visual Analog Scale (VAS) 0-180min (Measured from baseline to 90min every 15min; 90-180min every 30min)
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